Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | ESR1 | P03372 | 11/20 | 0.42 |
| ▸ | ESR2 | Q92731 | 9/20 | 0.42 |
| ▸ | ELANE | P08246 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 2/20 | 0.40 |
| ▸ | PPARA | Q07869 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501340 | 0.92 | ELANE (0.48) | MAPTTP53KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8497554 | 0.91 | L3MBTL1 (0.51) | MAPTTP53KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8500438 | 0.90 | MAPT (0.44) | MAPTTP53KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8499778 | 0.88 | ESR1 (0.54) | MAPTKMT2ASMN1; SMN2NPC1NFKB1 | |
| SCHEMBL8500292 | 0.88 | ESR1 (0.47) | MAPTTP53KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8500428 | 0.86 | ESR1 (0.41) | ESR1ESR2TDP1L3MBTL1PPARG | |
| SCHEMBL8501462 | 0.85 | ESR1 (0.47) | MAPTTP53KMT2AESR1ESR2 | |
| SCHEMBL8497550 | 0.83 | ESR1 (0.49) | MAPTTP53KMT2ASMN1; SMN2NPC1 | |
| SCHEMBL8500385 | 0.82 | TDP1 (0.47) | MAPTTP53ELANETDP1L3MBTL1 | |
| SCHEMBL8500225 | 0.82 | ESR1 (0.48) | KMT2AESR1ESR2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |