Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | PPID | Q08752 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | CASR | P41180 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDR | P35968 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8500098 | 0.89 | PPARG (0.50) | MAPK1TP53LMNAALDH1A1HPGD | |
| SCHEMBL8497486 | 0.86 | MAPT (0.46) | MAPTTP53LMNAALDH1A1NPSR1 | |
| SCHEMBL7861953 | 0.86 | NAMPT (0.55) | NAMPTMAPTTHRBMAPK1LMNA | |
| SCHEMBL8499211 | 0.84 | LMNA (0.54) | NAMPTMAPTTHRBMAPK1LMNA | |
| SCHEMBL8437250 | 0.84 | NAMPT (0.47) | NAMPTMAPTTHRBMAPK1TP53 | |
| SCHEMBL7372874 | 0.83 | NAMPT (0.57) | NAMPTMAPTTHRBMAPK1TP53 | |
| SCHEMBL7340251 | 0.83 | MAPT (0.54) | NAMPTMAPTTHRBMAPK1LMNA | |
| SCHEMBL7414819 | 0.81 | HSD17B10 (0.50) | NAMPTMAPTTP53ALDH1A1NPSR1 | |
| SCHEMBL7861966 | 0.80 | NAMPT (0.55) | NAMPTMAPTTHRBMAPK1LMNA | |
| SCHEMBL8428817 | 0.79 | PKM (0.50) | NAMPTMAPK1TP53LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0889877-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1999-01-13 | — | — | EP | claimed |
| WO-1997036862-A1 | META-SUBSTITUTED PHENYLENE DERIVATIVES AND THEIR USE AS ALPHAvBETA3 INTEGRIN ANTAGONISTS OR INHIBITORS | G.D. SEARLE & CO. (US) | 1997-10-09 | — | — | WO | claimed |