Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 4/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP1 | P29466 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8497579 | 0.93 | SMN1; SMN2 (0.42) | KDM4EESR1ESR2KMT2AMAPT | |
| SCHEMBL8501462 | 0.90 | ESR1 (0.47) | KDM4EESR1ESR2KMT2AMEN1 | |
| SCHEMBL8500225 | 0.89 | ESR1 (0.48) | KDM4EESR1ESR2KMT2AMEN1 | |
| SCHEMBL8501430 | 0.89 | ESR1 (0.46) | KDM4EESR1ESR2MAPTNPSR1 | |
| SCHEMBL8497550 | 0.86 | ESR1 (0.49) | KDM4EESR1ESR2KMT2AMEN1 | |
| SCHEMBL8502205 | 0.86 | MTNR1A (0.43) | ESR1ESR2THRBGAA | |
| SCHEMBL8497879 | 0.86 | KMT2A (0.42) | KDM4EESR1ESR2KMT2AMAPT | |
| SCHEMBL8501413 | 0.84 | AKR1C3 (0.42) | ESR1ESR2PTGS2 | |
| SCHEMBL8497702 | 0.83 | ESR1 (0.49) | ESR1ESR2KMT2AMEN1THRB | |
| SCHEMBL8497439 | 0.82 | ESR1 (0.49) | KDM4EESR1ESR2ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | claimed |
| US-5916916-A | USEFUL AS SELECTIVE ESTROGEN RECEPTOR MODULATORS. | ELI LILLY AND COMPANY (US) | 1999-06-29 | — | — | US | disclosed |