Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 5/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | ANPEP | P15144 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CCR5 | P51681 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8498357 | 0.79 | MMP2 (0.37) | CYP2C19CYP3A4CYP2D6CYP2C9APP | |
| SCHEMBL8527277 | 0.79 | CHRM4 (0.38) | CYP2C19CYP3A4CYP2D6CYP2C9APP | |
| SCHEMBL8498342 | 0.76 | MMP1 (0.39) | CYP2C19CYP3A4CYP2D6CYP2C9ALDH1A1 | |
| SCHEMBL8501600 | 0.72 | MMP2 (0.35) | CYP2C19CYP3A4CYP2D6CYP2C9APP | |
| SCHEMBL8499616 | 0.71 | MMP2 (0.36) | CYP2C19CYP3A4CYP2D6CYP2C9APP | |
| SCHEMBL8501409 | 0.71 | MMP9 (0.45) | APPALDH1A1MMP2 | |
| SCHEMBL8501553 | 0.69 | MMP2 (0.37) | CYP2C19CYP3A4CYP2D6CYP2C9APP | |
| SCHEMBL8502529 | 0.69 | USP30 (0.37) | HTTMMP2ANPEP | |
| SCHEMBL16865191 | 0.67 | MAPT (0.41) | CYP2C19CYP3A4CYP2D6CYP2C9ALDH1A1 | |
| SCHEMBL2770703 | 0.67 | CYP3A4 (0.42) | CYP2C19CYP3A4CYP2D6CYP2C9APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927161-A1 | SUBSTITUTED CYCLIC AMINE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998008815-A1 | SUBSTITUTED CYCLIC AMINE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |