Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 5/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.31 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8498357 | 0.80 | MMP2 (0.37) | MMP2ANPEPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8527277 | 0.80 | CHRM4 (0.38) | MMP2ANPEPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8498342 | 0.77 | MMP1 (0.39) | CYP3A4CYP2C9CYP2C19CYP2D6PKM | |
| SCHEMBL8499616 | 0.73 | MMP2 (0.36) | MMP2ANPEPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8501412 | 0.72 | CYP2C19 (0.36) | MMP2ANPEPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8501553 | 0.71 | MMP2 (0.37) | MMP2ANPEPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8502529 | 0.70 | USP30 (0.37) | MMP2ANPEP | |
| SCHEMBL8501596 | 0.70 | MMP9 (0.44) | MMP2PKM | |
| SCHEMBL16865191 | 0.69 | MAPT (0.41) | MMP2ANPEPCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL8502017 | 0.66 | HCRTR1 (0.34) | MMP2GAAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927161-A1 | SUBSTITUTED CYCLIC AMINE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998008815-A1 | SUBSTITUTED CYCLIC AMINE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |