Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501838 | 0.98 | ALDH1A1 (0.37) | ALDH1A1HPGDTSHRNPC1RAB9A | |
| SCHEMBL11748723 | 0.77 | ALDH1A1 (0.40) | ALDH1A1HPGDTSHRNPC1RAB9A | |
| SCHEMBL12383641 | 0.76 | ALDH1A1 (0.37) | ALDH1A1HPGDTSHRNPC1RAB9A | |
| SCHEMBL14733276 | 0.71 | ALOX15 (0.50) | HPGD | |
| SCHEMBL31727453 | 0.71 | HDAC1 (0.37) | ALDH1A1TSHRNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL15357893 | 0.71 | GABRA1 (0.33) | — | |
| SCHEMBL23529793 | 0.70 | HTT (0.35) | ALDH1A1 | |
| SCHEMBL31619918 | 0.70 | HTT (0.35) | ALDH1A1 | |
| Hydrochloric Acid SCHEMBL10953239 | 0.68 | — | — | |
| Hydrochloric Acid SCHEMBL10952207 | 0.68 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599270-B1 | Method of detecting phosphatase | AISIN SEIKI (JP) | 1999-05-12 | — | — | EP | claimed |
| EP-0599270-A2 | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1994-06-01 | — | — | EP | claimed |
| EP-0599270-B1 | Method of detecting phosphatase | AISIN SEIKI (JP) | 1999-05-12 | — | — | EP | disclosed |
| US-5480791-A | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1996-01-02 | — | — | US | disclosed |
| EP-0599270-A2 | Method of detecting phosphatase | AISIN SEIKI KABUSHIKI KAISHA (JP) | 1994-06-01 | — | — | EP | disclosed |