Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.59 |
| ▸ | F2 | P00734 | 3/20 | 0.47 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CTSB | P07858 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6636248 | 0.84 | F2 (0.47) | L3MBTL1F2MEN1CYP3A4CYP2C9 | |
| SCHEMBL16993182 | 0.83 | L3MBTL1 (0.62) | L3MBTL1PPARANPSR1ALDH1A1LMNA | |
| SCHEMBL13280913 | 0.83 | F2 (0.46) | L3MBTL1F2MEN1CYP3A4CYP2C9 | |
| SCHEMBL4344800 | 0.81 | L3MBTL1 (0.59) | L3MBTL1PPARAMEN1KMT2ANPSR1 | |
| SCHEMBL6987866 | 0.81 | L3MBTL1 (0.59) | L3MBTL1PPARANPSR1ALDH1A1LMNA | |
| SCHEMBL8329367 | 0.80 | L3MBTL1 (0.58) | L3MBTL1PPARANPSR1ALDH1A1LMNA | |
| SCHEMBL4344803 | 0.80 | L3MBTL1 (0.58) | L3MBTL1PPARANPSR1ALDH1A1LMNA | |
| SCHEMBL1624311 | 0.80 | SMN1; SMN2 (0.51) | L3MBTL1F2MEN1CYP3A4CYP2C9 | |
| SCHEMBL27572033 | 0.80 | TP53 (0.54) | L3MBTL1F2MEN1CYP3A4CYP2C9 | |
| SCHEMBL7754342 | 0.79 | L3MBTL1 (0.57) | L3MBTL1PPARANPSR1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5864045-A | Heterocyclic substituted piperazinone derivatives | HOECHST MARION ROUSSEL, INC. (US) | 1999-01-26 | — | — | US | disclosed |
| US-5840726-A | Heterocyclic substituted piperazinone derivatives | HOECHST MARION ROUSSEL INC. (US) | 1998-11-24 | — | — | US | disclosed |