Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | CALM1 | P0DP23 | 3/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | LTA4H | P09960 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.49 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30303113 | 0.90 | PPARG (0.52) | MAPK1L3MBTL1CALM1 | |
| SCHEMBL1032004 | 0.89 | KDM4E (0.62) | KMT2AMEN1KDM4EATMLTA4H | |
| SCHEMBL28176844 | 0.89 | KDM4E (0.62) | KMT2AMEN1KDM4EATMLTA4H | |
| SCHEMBL5607847 | 0.88 | CALM1 (0.56) | MAPK1L3MBTL1CALM1HDAC1HDAC2 | |
| SCHEMBL3673329 | 0.88 | FFAR4 (0.61) | L3MBTL1CALM1HDAC1HDAC2KMT2A | |
| Hydrochloric Acid SCHEMBL10448977 | 0.87 | KDM4E (0.61) | KMT2AMEN1KDM4EATMLTA4H | |
| SCHEMBL7995941 | 0.87 | FFAR4 (0.60) | L3MBTL1CALM1HDAC1HDAC2KMT2A | |
| SCHEMBL21494459 | 0.87 | PDE4D (0.59) | L3MBTL1CALM1HDAC1HDAC2KMT2A | |
| SCHEMBL4684155 | 0.86 | ALDH1A1 (0.50) | MAPK1CALM1KMT2AMEN1 | |
| SCHEMBL4426911 | 0.85 | CDK8 (0.55) | MAPK1L3MBTL1CALM1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0918746-A1 | IMMUNOTHERAPEUTIC AGENTS AND THEIR USE IN THE REDUCTION OF CYTOKINE LEVELS | CELGENE CORPORATION (US) | 1999-06-02 | — | — | EP | claimed |
| WO-1998006692-A1 | NOVEL IMMUNOTHERAPEUTIC AGENTS AND THEIR USE IN THE REDUCTION OF CYTOKINE LEVELS | CELGENE CORPORATION (US) | 1998-02-19 | — | — | WO | claimed |