Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 10/20 | 0.43 |
| ▸ | NPC1 | O15118 | 9/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.43 |
| ▸ | RELA | Q04206 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 1/20 | 0.42 |
| ▸ | NOS1 | P29475 | 1/20 | 0.42 |
| ▸ | NOS2 | P35228 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 4/20 | 0.41 |
| ▸ | GALR3 | O60755 | 1/20 | 0.41 |
| ▸ | STAT3 | P40763 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8501993 | 0.73 | SMN1; SMN2 (0.45) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| SCHEMBL8503495 | 0.69 | NOS2 (0.78) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| SCHEMBL29538889 | 0.68 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| SCHEMBL1306777 | 0.68 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| SCHEMBL5738051 | 0.67 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| SCHEMBL5738053 | 0.67 | RAB9A (0.70) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| SCHEMBL8503548 | 0.67 | NOS2 (0.78) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| SCHEMBL8502308 | 0.66 | RAB9A (0.71) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| SCHEMBL12980846 | 0.66 | RAB9A (0.56) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 | |
| SCHEMBL8500232 | 0.65 | NOS3 (0.56) | RAB9ANPC1SMN1; SMN2KMT2ANFKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5998445-A | PEPTIC ULCERS | EISAI CO., LTD. (JP) | 1999-12-07 | — | — | US | disclosed |
| EP-0786461-A1 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same | Eisai Co., Ltd. (JP) | 1997-07-30 | — | — | EP | disclosed |
| EP-0654471-A1 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and process for preparing the same | Eisai Co., Ltd. (JP) | 1995-05-24 | — | — | EP | disclosed |
| EP-0475456-A1 | Pyridine derivatives, pharmaceutical compositions comprising the same, the use of the same for the manufacture of medicaments having therapeutic or preventative value, and a process for preparing the same | Eisai Co., Ltd. (JP) | 1992-03-18 | — | — | EP | disclosed |
| US-5045552-A | Pyridine derivatives having anti-ulcerative activity | EISAI CO., LTD. (JP) | 1991-09-03 | — | — | US | disclosed |