Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 9/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.56 |
| ▸ | RECQL | P46063 | 8/20 | 0.56 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | BLM | P54132 | 6/20 | 0.56 |
| ▸ | LMNA | P02545 | 5/20 | 0.56 |
| ▸ | APEX1 | P27695 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.56 |
| ▸ | THPO | P40225 | 2/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | MTOR | P42345 | 1/20 | 0.56 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.51 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29430086 | 0.82 | TDP1 (0.53) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL28241555 | 0.82 | TDP1 (0.53) | TDP1KDM4ERECQLMAPTBLM | |
| Hydrochloric Acid SCHEMBL10340416 | 0.81 | KDM4E (0.55) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL29639815 | 0.78 | FFAR2 (0.47) | KDM4EMAPTLMNAHIF1AMAPK1 | |
| SCHEMBL1133517 | 0.76 | TDP1 (0.55) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL10721569 | 0.76 | TDP1 (0.55) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL6340898 | 0.75 | TDP1 (0.46) | TDP1KDM4ERECQLMAPTBLM | |
| SCHEMBL1677147 | 0.74 | FFAR2 (0.62) | LMNAKMT2AADRB2MEN1 | |
| SCHEMBL11316797 | 0.74 | FFAR2 (0.42) | — | |
| SCHEMBL17892146 | 0.74 | ALOX5 (0.53) | KMT2APOLBHPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0414730-B1 | Chemical Compounds and pharmaceutical compositions capable of releasing a drug | MILLS RANDELL L (US) | 1999-12-15 | — | — | EP | disclosed |