Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 4/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | ACP1 | P24666 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8498357 | 0.72 | MMP2 (0.37) | HCRTR1HCRTR2MMP2KMT2AMAPT | |
| SCHEMBL8527277 | 0.72 | CHRM4 (0.38) | MMP2KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL8498342 | 0.69 | MMP1 (0.39) | KMT2AMAPTKDM4EALDH1A1HPGD | |
| SCHEMBL8501412 | 0.67 | CYP2C19 (0.36) | MMP2KMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL8501600 | 0.66 | MMP2 (0.35) | MMP2PKMGAA | |
| SCHEMBL8499616 | 0.65 | MMP2 (0.36) | HCRTR1HCRTR2MMP2KMT2AALDH1A1 | |
| SCHEMBL8501553 | 0.64 | MMP2 (0.37) | MMP2KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL8502529 | 0.63 | USP30 (0.37) | MMP2 | |
| SCHEMBL16865191 | 0.62 | MAPT (0.41) | MMP2KMT2AMAPTKDM4EALDH1A1 | |
| SCHEMBL2770703 | 0.60 | CYP3A4 (0.42) | MMP2KMT2AMAPTKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0927161-A1 | SUBSTITUTED CYCLIC AMINE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1999-07-07 | — | — | EP | disclosed |
| WO-1998008815-A1 | SUBSTITUTED CYCLIC AMINE METALLOPROTEASE INHIBITORS | THE PROCTER & GAMBLE COMPANY (US) | 1998-03-05 | — | — | WO | disclosed |