SCHEMBL8503754

SCHEMBL8503754

CN1CCc2c([nH]c3ccccc23)C(c2ccccc2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
DRD2 P14416 2/20 0.54
DRD1 P21728 2/20 0.54
DRD5 P21918 2/20 0.54
ADRA1D P25100 2/20 0.54
ADRA1A P35348 2/20 0.54
ADRA1B P35368 2/20 0.54
KDM4E B2RXH2 2/20 0.52
CYP3A4 P08684 2/20 0.51
CYP2D6 P10635 2/20 0.51
CYP2C19 P33261 2/20 0.51
HTR7 P34969 1/20 0.51
SIGMAR1 Q99720 3/20 0.50
ABCB1 P08183 1/20 0.50
ABCG2 Q9UNQ0 1/20 0.50
CHRNA7 P36544 1/20 0.49
POLB P06746 1/20 0.48
MEN1 O00255 1/20 0.48
GMNN O75496 1/20 0.48
CYP1A2 P05177 1/20 0.48
CYP2C9 P11712 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11823184 0.87 DRD2 (0.58) DRD2DRD1DRD5ADRA1DADRA1A
SCHEMBL26017454 0.82 ADRA1D (0.57) DRD2DRD1DRD5ADRA1DADRA1A
SCHEMBL8803150 0.78 DRD1 (0.54) DRD2DRD1DRD5ADRA1AKDM4E
SCHEMBL17518851 0.78 ADRA1D (0.64) ADRA1DADRA1AADRA1BCYP3A4CYP2D6
SCHEMBL10688707 0.77 ADRA1D (0.56) DRD2DRD1DRD5ADRA1DADRA1A
SCHEMBL9610867 0.77 BRD3 (0.65) ADRA1DADRA1AADRA1BCYP3A4CYP2D6
SCHEMBL9665012 0.77 BRD3 (0.65) ADRA1DADRA1AADRA1BCYP3A4CYP2D6
SCHEMBL9610870 0.77 BRD3 (0.65) ADRA1DADRA1AADRA1BCYP3A4CYP2D6
SCHEMBL19558158 0.75 ADRA1D (0.59) ADRA1DADRA1AADRA1BHTR7SIGMAR1
SCHEMBL8503944 0.73 HTR7 (0.62) DRD2ADRA1DADRA1AADRA1BKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0910567-A1 TRICYCLIC IBOGAINE ANALOGS, THEIR PREPARATION AND THEIR USE IN TREATING SUBSTANCE ABUSE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 1999-04-28 EP disclosed
WO-1997020847-A1 TRICYCLIC IBOGAINE ANALOGS, THEIR PREPARATION AND THEIR USE IN TREATING SUBSTANCE ABUSE REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 1997-06-12 WO disclosed
US-5616575-A COCAINE ADDICTION REGENTS OF THE UNIVERSITY OF MINNESOTA (US) 1997-04-01 US disclosed