Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 4/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8924801 | 0.85 | MTNR1A (0.43) | MTNR1AMTNR1BALDH1A1NR1I2KDM4E | |
| SCHEMBL24254051 | 0.82 | ALDH1A1 (0.46) | ALDH1A1NR1I2MEN1KMT2AF10 | |
| SCHEMBL8502442 | 0.82 | MAPT (0.46) | MTNR1AMTNR1BALDH1A1NR1I2MEN1 | |
| SCHEMBL8762406 | 0.77 | ALDH1A1 (0.41) | ALDH1A1NR1I2MEN1KMT2AF10 | |
| SCHEMBL2156670 | 0.77 | AKR1C3 (0.48) | ALDH1A1NR1I2MEN1KMT2AF10 | |
| SCHEMBL29954247 | 0.76 | ERN1 (0.49) | ALDH1A1NR1I2TSHRNPSR1F10 | |
| SCHEMBL3225589 | 0.76 | NR1I2 (0.41) | ALDH1A1NR1I2TSHRNPSR1MEN1 | |
| SCHEMBL7962276 | 0.75 | AKR1C3 (0.41) | MTNR1AMTNR1BALDH1A1NR1I2MEN1 | |
| SCHEMBL19930245 | 0.75 | KCNQ4 (0.40) | MAPT | |
| SCHEMBL3584387 | 0.74 | PIK3CG (0.41) | MTNR1AMTNR1BALDH1A1NR1I2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919943-A | INHIBITION OF SPLA2 | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5919810-A | SEPTIC SHOCK | ELI LILLY AND COMPANY (US) | 1999-07-06 | — | — | US | disclosed |
| US-5733923-A | SECRETORY PANCREATIC PHOSPHOLIPASE A2 | ELI LILLY AND COMPANY (US) | 1998-03-31 | — | — | US | disclosed |
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |