Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 6/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 5/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.38 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8502442 | 0.93 | MAPT (0.46) | MTNR1AMTNR1BKDM4ENPC1LMNA | |
| SCHEMBL8505209 | 0.85 | MTNR1A (0.39) | MTNR1AMTNR1BKDM4ENPC1MAPT | |
| SCHEMBL24254051 | 0.83 | ALDH1A1 (0.46) | MAPTSMN1; SMN2ALDH1A1NR1I2 | |
| SCHEMBL7963161 | 0.83 | KMT2A (0.40) | TP53CYP3A4MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL7962276 | 0.79 | AKR1C3 (0.41) | MTNR1AMTNR1BKDM4ENPC1MAPT | |
| SCHEMBL8762406 | 0.78 | ALDH1A1 (0.41) | KDM4ENPC1RAB9AALDH1A1NR1I2 | |
| SCHEMBL2156670 | 0.78 | AKR1C3 (0.48) | SMN1; SMN2ALDH1A1NR1I2 | |
| SCHEMBL3584387 | 0.78 | PIK3CG (0.41) | MTNR1AMTNR1BKDM4ELMNAMAPT | |
| SCHEMBL3225589 | 0.77 | NR1I2 (0.41) | LMNAALDH1A1POLBNR1I2 | |
| SCHEMBL13316203 | 0.77 | PIK3CG (0.46) | SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684034-A | INHIBITORS OF HUMAN NON-PANCREATIC SECRETORY PHOSPHOLIPASE A2, TREATMENT OF SEPTIC SHOCK, TRAUMA, RESPIRATORY DISORDERS, RHEUMATIC ARTHRITIS, INHIBITORS OF ARACHIDONIC ACID RELEASE | ELI LILLY AND COMPANY (US) | 1997-11-04 | — | — | US | disclosed |