Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8506797 | 1.00 | SIGMAR1 (0.36) | SIGMAR1MAPK1SMN1; SMN2LMNACHRM2 | |
| SCHEMBL8507270 | 0.80 | PGR (0.38) | SIGMAR1LMNACHRM2HTR2APGR | |
| SCHEMBL7936583 | 0.76 | CHRM2 (0.40) | SIGMAR1LMNACHRM2HTR2APGR | |
| SCHEMBL10952661 | 0.74 | LMNA (0.49) | SIGMAR1MAPK1SMN1; SMN2LMNACHRM2 | |
| SCHEMBL8506823 | 0.72 | SLC6A2 (0.40) | SIGMAR1MAPK1SMN1; SMN2LMNACHRM2 | |
| SCHEMBL15908335 | 0.68 | LMNA (0.54) | SIGMAR1MAPK1SMN1; SMN2LMNACHRM2 | |
| SCHEMBL19130507 | 0.68 | SIGMAR1 (0.41) | SIGMAR1MAPK1SMN1; SMN2LMNAHTR2A | |
| SCHEMBL8506381 | 0.68 | SIGMAR1 (0.38) | SIGMAR1MAPK1SMN1; SMN2LMNACHRM2 | |
| SCHEMBL29501701 | 0.67 | SIGMAR1 (0.43) | SIGMAR1HTR2A | |
| SCHEMBL30511096 | 0.67 | PGR (0.49) | SMN1; SMN2LMNAPGRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733035-B1 | TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORP (US) | 1999-03-31 | — | — | EP | disclosed |
| EP-0733035-A1 | TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1996-09-25 | — | — | EP | disclosed |
| US-5538986-A | INHIBITORS OF TUMOR NECROSIS FACTOR-ALPHA, DIBENZOCYCLOHEPTANE AND DIBENZOXEPINE DERIVATIVES | SCHERING CORPORATION (US) | 1996-07-23 | — | — | US | disclosed |
| WO-1995015939-A1 | TRICYCLIC DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1995-06-15 | — | — | WO | disclosed |