Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | PGR | P06401 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.33 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.33 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.33 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.33 |
| ▸ | CES1 | P23141 | 1/20 | 0.33 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.33 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8507270 | 0.83 | PGR (0.38) | CHRM2ADRA2ASIGMAR1HTR2APGR | |
| SCHEMBL4000051 | 0.81 | CHRM2 (0.53) | CHRM2ADRA2ASIGMAR1HTR2AHTR2C | |
| SCHEMBL8506797 | 0.76 | SIGMAR1 (0.36) | CHRM2SIGMAR1HTR2APGRLMNA | |
| SCHEMBL8506801 | 0.76 | SIGMAR1 (0.36) | CHRM2SIGMAR1HTR2APGRLMNA | |
| SCHEMBL2046093 | 0.75 | CPT1A (0.33) | — | |
| SCHEMBL8506823 | 0.75 | SLC6A2 (0.40) | CHRM2ADRA2ASIGMAR1HTR2AHTR2C | |
| SCHEMBL8506381 | 0.75 | SIGMAR1 (0.38) | CHRM2ADRA2ASIGMAR1HTR2AHTR2C | |
| SCHEMBL10952661 | 0.74 | LMNA (0.49) | CHRM2SIGMAR1HTR2ALMNATSHR | |
| SCHEMBL3013289 | 0.73 | LMNA (0.42) | HTR2APGRLMNANPC1CES1 | |
| SCHEMBL7935803 | 0.72 | ALDH1A1 (0.46) | CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6331636-B1 | TREATMENT OF CENTRAL NERVOUS SYSTEM DISORDERS, DIABETES, HYPERTENSION, IMPOTENCY, APPETITE CONTROL | THE UPJOHN COMPANY | 2001-12-18 | — | — | US | disclosed |
| EP-0482084-B1 | (1,2N) AND (3,2N)-CARBOCYCLIC-2-AMINO TETRALIN DERIVATIVES | UPJOHN CO (US) | 1997-05-07 | — | — | EP | disclosed |
| US-5545755-A | USEFUL TO TREAT CENTRAL NERVOUS SYSTEM DISORDERS, HYPERTENSION, DIABETES, SEXUAL IMPOTENCY AND TO CONTROL APPETITE | THE UPJOHN COMPANY (US) | 1996-08-13 | — | — | US | disclosed |
| US-5491236-A | NERVOUS SYTEM DISORDERS | THE UPJOHN COMPANY (US) | 1996-02-13 | — | — | US | disclosed |
| EP-0552246-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1993-07-28 | — | — | EP | disclosed |
| WO-1992006967-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1992-04-30 | — | — | WO | disclosed |
| EP-0482084-A1 | (1,2N) AND (3,2N)-CARBOCYCLIC-2-AMINO TETRALIN DERIVATIVES. | UPJOHN CO (US) | 1992-04-29 | — | — | EP | disclosed |
| EP-0476016-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | PHARMACIA & UPJOHN COMPANY (US) | 1992-03-25 | — | — | EP | disclosed |
| WO-1991000856-A2 | (1,2N) AND (3,2N)-CARBOCYCLIC-2-AMINO TETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1991-01-24 | — | — | WO | disclosed |
| WO-1990015047-A1 | THERAPEUTICALLY USEFUL 2-AMINOTETRALIN DERIVATIVES | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |