Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.36 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11724613 | 0.77 | MEN1 (0.41) | MEN1KMT2AALDH1A1KDM4EALOX15 | |
| SCHEMBL9740818 | 0.72 | ALDH1A1 (0.52) | ALDH1A1KDM4E | |
| SCHEMBL10425283 | 0.72 | ALDH1A1 (0.52) | ALDH1A1KDM4E | |
| SCHEMBL8504688 | 0.68 | PTAFR (0.40) | ALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL58587 | 0.67 | KMT2A (0.54) | MEN1KMT2AKDM4EALOX15CYP1A2 | |
| SCHEMBL57526 | 0.67 | KMT2A (0.54) | MEN1KMT2AKDM4EALOX15CYP1A2 | |
| SCHEMBL10670936 | 0.67 | KDM4E (0.54) | ALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL8504663 | 0.67 | KDM4E (0.54) | ALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL27671871 | 0.67 | KDM4E (0.54) | ALDH1A1KDM4ERAB9AGAA | |
| SCHEMBL9853982 | 0.67 | KDM4E (0.45) | MEN1KMT2AALDH1A1KDM4EALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0595924-B1 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 1999-04-14 | — | — | EP | disclosed |
| US-5459152-A | 3-(pyridin-3-yl)-7-(indol-3-yl)carbonyl-1H,3H-pyrrolo(1,2-c) thiazole derivatives; asthma | ABBOTT LABORATORIES (US) | 1995-10-17 | — | — | US | disclosed |
| EP-0595924-A4 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LAB (US) | 1994-08-24 | — | — | EP | disclosed |
| EP-0595924-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1994-05-11 | — | — | EP | disclosed |
| WO-1993001813-A1 | PLATELET ACTIVATING FACTOR ANTAGONISTS | ABBOTT LABORATORIES (US) | 1993-02-04 | — | — | WO | disclosed |
| US-4529728-A | 1H,3H-pyrrolo[1,2-c]thiazole derivatives having anti-allergic and anti-inflammatory activity | RHONE-POULENC SANTE (FR) | 1985-07-16 | — | — | US | disclosed |