Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10425283 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KDM4EMAPTHSD17B10 | |
| SCHEMBL9250005 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPT | |
| SCHEMBL9250009 | 0.82 | ALDH1A1 (0.54) | ALDH1A1KDM4EMAPT | |
| SCHEMBL9853982 | 0.81 | KDM4E (0.45) | ALDH1A1KDM4E | |
| SCHEMBL27314597 | 0.80 | ALDH1A1 (0.45) | ALDH1A1KDM4EMAPT | |
| SCHEMBL9853999 | 0.80 | POLB (0.58) | ALDH1A1KDM4EHSD17B10 | |
| Acetic Acid SCHEMBL9854087 | 0.79 | POLB (0.57) | ALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9647783 | 0.78 | PTAFR (0.56) | — | |
| SCHEMBL9268772 | 0.78 | — | — | |
| SCHEMBL10647450 | 0.77 | PTAFR (0.64) | ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124459-A | Process for the preparation of 3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile | RHONE-POULENC SANTE (FR) | 1992-06-23 | — | — | US | claimed |
| US-4906757-A | Process for the preparation of dextrorotatory 3-(3-pyridyl)-1H,3H-pyrrolo [1,2-c]-7-thiazolecarboxylic acid | RHONE-POULENC SANTE (FR) | 1990-03-06 | — | — | US | claimed |
| JP-1250387-A | — | — | None | — | — | JP | disclosed |
| US-5124459-A | Process for the preparation of 3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile | RHONE-POULENC SANTE (FR) | 1992-06-23 | — | — | US | disclosed |
| US-5124459-A | Process for the preparation of 3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]thiazole-7-carbonitrile | RHONE-POULENC SANTE (FR) | 1992-06-23 | — | — | US | disclosed |
| US-4987132-A | PLATELET ACTIVATING FACTOR ANTAGONISTS | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 1991-01-22 | — | — | US | disclosed |
| US-4906757-A | Process for the preparation of dextrorotatory 3-(3-pyridyl)-1H,3H-pyrrolo [1,2-c]-7-thiazolecarboxylic acid | RHONE-POULENC SANTE (FR) | 1990-03-06 | — | — | US | disclosed |
| US-4906757-A | Process for the preparation of dextrorotatory 3-(3-pyridyl)-1H,3H-pyrrolo [1,2-c]-7-thiazolecarboxylic acid | RHONE-POULENC SANTE (FR) | 1990-03-06 | — | — | US | disclosed |
| JP-H01250387-A | PREPARATION OF 3-(3-PYRIMIDYL)-1H,3H-PYRROLO(1,2-C)THIAZOLE-7-CARBONITIRILE | RHONE POULENC SANTE | 1989-10-05 | — | — | JP | disclosed |
| EP-0327417-A1 | Process for the preparation of 3-(3-pyridyl)-1H,3H-pyrrolo[1,2-c]-thiazole-7-carbonitrile | RHONE-POULENC SANTE (FR) | 1989-08-09 | — | — | EP | disclosed |
| EP-0297987-A1 | Process for the preparation of dextro (3-pyridyl)-3-1H,3H-pyrrolo [1,2-c] thiazole-7-carboxylic acid | RHONE-POULENC SANTE (FR) | 1989-01-04 | — | — | EP | disclosed |
| EP-0279681-A2 | Saturated heterocyclic carboxamide derivatives | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1988-08-24 | — | — | EP | disclosed |
| US-4539400-A | Pyridin-3-yl substituted ortho-fused pyrrole derivatives | RHONE-POULENC SANTE (FR) | 1985-09-03 | — | — | US | disclosed |
| US-4529728-A | 1H,3H-pyrrolo[1,2-c]thiazole derivatives having anti-allergic and anti-inflammatory activity | RHONE-POULENC SANTE (FR) | 1985-07-16 | — | — | US | disclosed |