Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7142115 | 0.85 | MEN1 (0.41) | PRMT5WDR77PDE4APDE4BPDE4C | |
| SCHEMBL7295826 | 0.82 | NPC1 (0.32) | — | |
| SCHEMBL4620956 | 0.82 | NPC1 (0.36) | KCNA5SCN5A | |
| SCHEMBL8510312 | 0.82 | KCNA5 (0.34) | KCNA5SCN5AACACB | |
| SCHEMBL7302580 | 0.81 | NPC1 (0.39) | KCNA5SCN5A | |
| SCHEMBL7306025 | 0.79 | HSD17B3 (0.31) | — | |
| SCHEMBL7304360 | 0.74 | FFAR4 (0.33) | — | |
| SCHEMBL7295050 | 0.74 | FFAR4 (0.33) | — | |
| SCHEMBL7304224 | 0.73 | OPRM1 (0.42) | SCN5A | |
| SCHEMBL7306774 | 0.73 | OPRM1 (0.39) | SCN5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966464-A1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998039328-A1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | F.HOFFMANN-LA ROCHE AG (CH) | 1998-09-11 | — | — | WO | disclosed |