Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 1/20 | 0.34 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.34 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 1/20 | 0.33 |
| ▸ | PRKDC | P78527 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14966407 | 0.91 | TAAR1 (0.35) | KCNA5SCN5ATAAR1HTR2AACACB | |
| SCHEMBL7142115 | 0.85 | MEN1 (0.41) | TAAR1LMNA | |
| SCHEMBL1422301 | 0.82 | TAAR1 (0.41) | TAAR1HTR2ACARM1PRMT6SMN1; SMN2 | |
| SCHEMBL8510243 | 0.82 | KCNA5 (0.32) | KCNA5SCN5AACACB | |
| SCHEMBL14967219 | 0.81 | TAAR1 (0.37) | KCNA5SCN5ATAAR1HTR2APRKDC | |
| SCHEMBL27989272 | 0.81 | TAAR1 (0.39) | TAAR1HTR2ACARM1PRMT6SMN1; SMN2 | |
| SCHEMBL27599996 | 0.74 | TAAR1 (0.36) | TAAR1HTR2A | |
| SCHEMBL29290702 | 0.73 | CHRNB2 (0.46) | — | |
| SCHEMBL4078714 | 0.72 | KDM4C (0.49) | KCNA5SCN5ATAAR1HTR2A | |
| SCHEMBL4079349 | 0.72 | KDM4C (0.49) | KCNA5SCN5ATAAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966464-A1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | F. HOFFMANN-LA ROCHE AG (CH) | 1999-12-29 | — | — | EP | disclosed |
| WO-1998039328-A1 | SUBSTITUTED 2,4-DIAMINOPYRIMIDINES | F.HOFFMANN-LA ROCHE AG (CH) | 1998-09-11 | — | — | WO | disclosed |