Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.35 |
| ▸ | RELA | Q04206 | 1/20 | 0.35 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.33 |
| ▸ | ATM | Q13315 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8510980 | 0.86 | PTGDR2 (0.42) | LMNASMN1; SMN2MAPTHTTALDH1A1 | |
| SCHEMBL30870662 | 0.80 | LMNA (0.40) | LMNASMN1; SMN2MAPTHTTALDH1A1 | |
| SCHEMBL15300774 | 0.80 | LMNA (0.40) | LMNASMN1; SMN2MAPTHTTALDH1A1 | |
| SCHEMBL8515160 | 0.75 | PTGDR2 (0.51) | LMNASMN1; SMN2MAPTHTTALDH1A1 | |
| SCHEMBL129673 | 0.74 | AR (0.49) | LMNASMN1; SMN2MAPTHTTALDH1A1 | |
| SCHEMBL7847441 | 0.73 | PTGDR2 (0.40) | HTTALDH1A1PTGDR2NPC1RAB9A | |
| SCHEMBL19513726 | 0.72 | NCEH1 (0.42) | LMNASMN1; SMN2MAPTALDH1A1PTGDR2 | |
| SCHEMBL2284093 | 0.72 | ALDH1A1 (0.43) | LMNASMN1; SMN2MAPTHTTALDH1A1 | |
| SCHEMBL4472584 | 0.71 | RAB9A (0.38) | MAPTALDH1A1POLBPTGDR2RAB9A | |
| SCHEMBL5715246 | 0.71 | ELANE (0.48) | LMNASMN1; SMN2MAPTHTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |