Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 3/20 | 0.44 |
| ▸ | KMO | O15229 | 1/20 | 0.43 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | SORD | Q00796 | 1/20 | 0.38 |
| ▸ | ITGB2 | P05107 | 2/20 | 0.38 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.38 |
| ▸ | ITGAL | P20701 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8512439 | 0.91 | DKK1 (0.56) | DKK1KMOMTORPIK3CASORD | |
| Hydrochloric Acid SCHEMBL8513412 | 0.90 | DKK1 (0.55) | DKK1KMOMTORPIK3CASORD | |
| SCHEMBL8514134 | 0.89 | DKK1 (0.42) | DKK1KMOMTOREGFRPIK3CA | |
| SCHEMBL8510840 | 0.89 | KMO (0.43) | DKK1KMOMTORLRRK2PIK3CA | |
| SCHEMBL8511678 | 0.88 | DKK1 (0.58) | DKK1KMOMTORPIK3CASORD | |
| SCHEMBL8514794 | 0.88 | DKK1 (0.41) | DKK1KMOMTORLRRK2PIK3CA | |
| Ammonia Solution, Strong SCHEMBL8587136 | 0.87 | DYRK1A (0.43) | DKK1KMOSORD | |
| SCHEMBL8515838 | 0.87 | DKK1 (0.49) | DKK1KMOLRRK2 | |
| SCHEMBL8511790 | 0.87 | ROCK2 (0.41) | DKK1KMOLRRK2EGFRPIK3CA | |
| SCHEMBL9612712 | 0.86 | DKK1 (0.40) | DKK1KMOMTORLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |