Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 2/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.43 |
| ▸ | KMO | O15229 | 1/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.39 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.37 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8512439 | 0.94 | DKK1 (0.56) | DKK1ROCK2DYRK1AKMOKARS1 | |
| Hydrochloric Acid SCHEMBL8513412 | 0.93 | DKK1 (0.55) | DKK1ROCK2DYRK1AKMOSUV39H2 | |
| Ammonia Solution, Strong SCHEMBL8587136 | 0.89 | DYRK1A (0.43) | DKK1DYRK1AKMO | |
| SCHEMBL8587138 | 0.88 | DKK1 (0.52) | DKK1ROCK2KMO | |
| SCHEMBL8510671 | 0.87 | DKK1 (0.44) | DKK1KMOLRRK2 | |
| SCHEMBL8511678 | 0.86 | DKK1 (0.58) | DKK1ROCK2KMO | |
| SCHEMBL8514134 | 0.84 | DKK1 (0.42) | DKK1KMORET | |
| SCHEMBL8510840 | 0.84 | KMO (0.43) | DKK1KMOLRRK2PIM1 | |
| SCHEMBL8510739 | 0.84 | ZAP70 (0.41) | DKK1ROCK2KMOLRRK2SUV39H2 | |
| SCHEMBL8510734 | 0.84 | ZAP70 (0.41) | DKK1ROCK2KMOLRRK2SUV39H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | claimed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |