Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 14/20 | 0.42 |
| ▸ | RARA | P10276 | 13/20 | 0.42 |
| ▸ | RARG | P13631 | 14/20 | 0.42 |
| ▸ | RXRA | P19793 | 4/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | RXRG | P48443 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8511463 | 0.81 | SYK (0.43) | RARBRARARARG | |
| Trifluoroacetic Acid SCHEMBL8511882 | 0.81 | RARB (0.39) | RARBRARARARGRXRAABCB1 | |
| SCHEMBL8515150 | 0.75 | EPHX2 (0.41) | — | |
| SCHEMBL8514108 | 0.72 | CHEK2 (0.44) | — | |
| SCHEMBL8515197 | 0.71 | RARB (0.42) | RARBRARARARGRXRAABCB1 | |
| SCHEMBL8513291 | 0.70 | GPR119 (0.52) | — | |
| SCHEMBL16612996 | 0.69 | RARA (0.47) | RARBRARARARGRXRAABCB1 | |
| SCHEMBL5267332 | 0.69 | MALT1 (0.45) | — | |
| SCHEMBL14121158 | 0.68 | SPR (0.40) | — | |
| SCHEMBL30757104 | 0.68 | SPR (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |