Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 3/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | SMO | Q99835 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.36 |
| ▸ | CDK2 | P24941 | 4/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.35 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.34 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.34 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8512387 | 0.99 | DKK1 (0.44) | DKK1RETRARARARBPIK3CA | |
| SCHEMBL8514868 | 0.83 | DKK1 (0.64) | DKK1RETRARARARBPIK3CA | |
| SCHEMBL8515262 | 0.83 | RARA (0.45) | RARARARBSMO | |
| SCHEMBL8511490 | 0.83 | DKK1 (0.42) | DKK1RARARARBPIK3CAPIK3CD | |
| Hydrochloric Acid SCHEMBL8612509 | 0.82 | RARA (0.44) | RARARARBSMO | |
| SCHEMBL12805010 | 0.82 | CKS1B (0.47) | DKK1RETRARARARBCCNE1 | |
| Hydrochloric Acid SCHEMBL8511494 | 0.82 | DKK1 (0.63) | DKK1RETRARARARBPIK3CA | |
| Hydrochloric Acid SCHEMBL8515565 | 0.82 | DKK1 (0.41) | DKK1RARARARBPIK3CAPIK3CD | |
| SCHEMBL2012211 | 0.80 | DKK1 (0.57) | DKK1RETRARARARBPIK3CA | |
| SCHEMBL2012214 | 0.80 | DKK1 (0.57) | DKK1RETRARARARBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | claimed |