SCHEMBL8511664

SCHEMBL8511664

CC(Oc1ccc(-c2ncc(Cl)cc2Cl)cc1O)C(=O)OC[Si](C)(C)C

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.40
MEN1 O00255 1/20 0.40
KMT2A Q03164 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
SMN1; SMN2 Q16637 2/20 0.37
MAPT P10636 1/20 0.36
ALDH1A1 P00352 4/20 0.35
KDM4E B2RXH2 2/20 0.35
GAA P10253 2/20 0.35
LMNA P02545 3/20 0.35
HTT P42858 2/20 0.35
HPGD P15428 3/20 0.34
TSHR P16473 1/20 0.34
MAPK1 P28482 1/20 0.34
NPSR1 Q6W5P4 1/20 0.34
PKM P14618 1/20 0.33
CYP1A2 P05177 1/20 0.33
GLA P06280 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2D6 P10635 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10515743 1.00 L3MBTL1 (0.40) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL9804353 0.91 TDP1 (0.36) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL9804293 0.91 TDP1 (0.36) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL732544 0.89 L3MBTL1 (0.46) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL11601818 0.88 L3MBTL1 (0.39) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL10760195 0.87 ALDH1A1 (0.40) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL9763694 0.85 TSHR (0.47) L3MBTL1KMT2ASMN1; SMN2ALDH1A1KDM4E
SCHEMBL6732935 0.85 TSHR (0.47) L3MBTL1KMT2ASMN1; SMN2ALDH1A1KDM4E
SCHEMBL10510541 0.85 ALDH1A1 (0.38) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL731517 0.85 L3MBTL1 (0.39) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4518416-A Certain trimethyl silyl-lower-alkyl esters of pyridyloxy-phenoxy-lower alkanoic acids, compositions containing same and herbicidal method of use BAYER AKTIENGESELLSCHAFT (DE) 1985-05-21 US claimed
EP-0113857-A1 Herbicidal agents BAYER AG (DE) 1984-07-25 EP claimed
US-5945541-A Plant protection agents based on pyrazolecarboxylic acid derivatives HOECHST SCHERING AGREVO GMBH (DE) 1999-08-31 US disclosed
EP-0635996-B1 PYRAZOLINES FOR THE PROTECTION OF CROP PLANTS AGAINST HERBICIDES HOECHST SCHERING AGREVO GMBH (DE) 1998-02-11 EP disclosed
US-5703008-A Pyrazolines for protecting crop plants against herbicides HOECHST AKTIENGESELLSCHAFT (DE) 1997-12-30 US disclosed
US-5700758-A APPLYING TO SAFEN PLANTS AGAINST PHOTOTOXICITY HOECHST AKTIENGESELLSCHAFT (DE) 1997-12-23 US disclosed
US-5401700-A Plant protection agents based on pyrazolecarboxylic acid derivatives HOECHST AKTIENGESELLSCHAFT (DE) 1995-03-28 US disclosed
EP-0635996-A1 PYRAZOLINES FOR THE PROTECTION OF CROPS AGAINST HERBICIDES Hoechst Schering AgrEvo GmbH (DE) 1995-02-01 EP disclosed
EP-0333131-B1 Plant protective agent based on pyrazolecarboxylic acid derivatives HOECHST AG (DE) 1993-10-27 EP disclosed
US-5103017-A PYRAZOLINES AND THEIR USE AS SAFENERS HOECHST AKTIENGESELLSCHAFT (DE) 1992-04-07 US disclosed
US-5082949-A Plant growth regulators, protective agents HOECHST AKTIENGESELLSCHAFT (DE) 1992-01-21 US disclosed
US-4769455-A Benzodisultams BAYER AKTIENGESELLSCHAFT (DE) 1988-09-06 US disclosed
EP-0170047-B1 PROCESS FOR THE PREPARATION OF LACTIC ACID SILYL ESTERS BAYER AG (DE) 1988-08-10 EP disclosed
EP-0269806-A1 Phenylpyrazole carbonic acid derivatives, their preparation and use as plant growth regulators and antidotes HOECHST AKTIENGESELLSCHAFT (DE) 1988-06-08 EP disclosed
US-4680052-A Herbicidal benzodisultam derivative, compositions and method of use therefor BAYER AKTIENGESELLSCHAFT (DE) 1987-07-14 US disclosed
EP-0203220-A1 Benzolactamsultams BAYER AG (DE) 1986-12-03 EP disclosed
EP-0173956-A1 Sulfonyl-guanidinotriazine derivatives BAYER AG (DE) 1986-03-12 EP disclosed
EP-0173321-A1 Sulfonyl-guanidinopyrimidine derivatives BAYER AG (DE) 1986-03-05 EP disclosed
EP-0170047-A1 Process for the preparation of lactic acid silyl esters BAYER AG (DE) 1986-02-05 EP disclosed
EP-0113857-A1 Herbicidal agents BAYER AG (DE) 1984-07-25 EP disclosed