SCHEMBL731517

SCHEMBL731517

C#CCOC(=O)C(C)Oc1ccc(-c2ncc(Cl)cc2Cl)cc1O

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
L3MBTL1 Q9Y468 2/20 0.39
MEN1 O00255 1/20 0.37
KMT2A Q03164 1/20 0.37
TDP1 Q9NUW8 1/20 0.37
SMN1; SMN2 Q16637 2/20 0.35
MAPT P10636 1/20 0.35
ALDH1A1 P00352 3/20 0.34
LMNA P02545 3/20 0.34
KDM4E B2RXH2 2/20 0.34
GAA P10253 2/20 0.34
HTT P42858 2/20 0.34
CYP2B6 P20813 1/20 0.34
HPGD P15428 3/20 0.33
TSHR P16473 1/20 0.33
MAPK1 P28482 1/20 0.33
PKM P14618 1/20 0.32
CYP1A2 P05177 1/20 0.32
GLA P06280 1/20 0.32
CYP3A4 P08684 1/20 0.32
CYP2D6 P10635 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7608524 0.92 P2RX3 (0.36) L3MBTL1MEN1KMT2ATDP1MAPT
SCHEMBL10791367 0.90 L3MBTL1 (0.32) L3MBTL1SMN1; SMN2ALDH1A1LMNAKDM4E
SCHEMBL732544 0.87 L3MBTL1 (0.46) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL11601818 0.86 L3MBTL1 (0.39) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL8511664 0.85 L3MBTL1 (0.40) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL10515743 0.85 L3MBTL1 (0.40) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL10792979 0.85 L3MBTL1 (0.34) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL10760195 0.85 ALDH1A1 (0.40) L3MBTL1MEN1KMT2ATDP1SMN1; SMN2
SCHEMBL6732935 0.84 TSHR (0.47) L3MBTL1KMT2ASMN1; SMN2ALDH1A1LMNA
SCHEMBL9763694 0.84 TSHR (0.47) L3MBTL1KMT2ASMN1; SMN2ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 252 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0330904-B1 Herbicidal agent in the form of aqueous microemulsions HOECHST AG (DE) 1994-04-20 EP claimed
EP-0094349-B1 Use of quinoline derivatives for the protection of cultivated plants CIBA GEIGY AG (CH) 1994-04-06 EP claimed
US-5102445-A Plant safening agent CIBA-GEIGY CORPORATION (US) 1992-04-07 US claimed
US-5045107-A From herbicides, plant safening agents CIBA-GEIGY CORPORATION (US) 1991-09-03 US claimed
US-4973352-A Herbicidal agents in the form of aqueous transparent microemulsions HOECHST AKTIENGESELLSCHAFT (DE) 1990-11-27 US claimed
US-4758264-A Selectively controlling weeds in crops CIBA-GEIGY CORPORATION (US) 1988-07-19 US claimed
EP-0043349-B1 SYNERGISTIC AGENTS AND METHOD FOR THE SELECTIVE CONTROL OF WEEDS, PARTICULARLY IN CEREALS AND SOYBEANS CIBA-GEIGY AG (CH) 1987-08-12 EP claimed
EP-0086750-B1 USE OF QUINOLINE DERIVATIVES IN THE PROTECTION OF CROP PLANTS CIBA-GEIGY AG (CH) 1987-07-08 EP claimed
EP-0086746-B1 PHENYLAMINO-OXO-ACETIC ACIDS AND THEIR ESTERS AS HERBICIDAL ANTIDOTES FOR THE PROTECTION OF CULTIVATED PLANTS CIBA-GEIGY AG (CH) 1986-07-30 EP claimed
EP-0094351-B1 CYCLOPROPANECARBOXYLIC-ACID DERIVATIVES CIBA-GEIGY AG (CH) 1986-07-23 EP claimed
EP-0069705-B1 SYNERGISTIC AGENT AND PROCESS FOR THE SELECTIVE CONTROL OF WEEDS, ESPECIALLY IN CROPS CIBA-GEIGY AG (CH) 1985-05-29 EP claimed
US-4505738-A Halovinyl-3,3-dimethylcyclopropanecarboxylic acid pyronyl esters useful for the protection of cultivated plants against the harmful effects of herbicides CIBA-GEIGY CORPORATION (US) 1985-03-19 US claimed
EP-0043802-B1 SYNERGISTIC AGENTS AND METHOD FOR THE SELECTIVE CONTROL OF WEEDS, PARTICULARLY IN CEREALS CIBA-GEIGY AG (CH) 1984-02-22 EP claimed
EP-0043800-A1 Synergistic agents and method for the selective control of weeds, particularly in sugar beets and fodder beets CIBA-GEIGY AG (CH) 1982-01-13 EP claimed
EP-0043802-A1 Synergistic agents and method for the selective control of weeds, particularly in cereals CIBA-GEIGY AG (CH) 1982-01-13 EP claimed
EP-0043349-A1 Synergistic agents and method for the selective control of weeds, particularly in cereals and soybeans CIBA-GEIGY AG (CH) 1982-01-06 EP claimed
US-9801374-B2 Active compound combinations comprising carboxamide derivatives BAYER CROPSCIENCE AG (DE) 2017-10-31 US disclosed
EP-1893016-B1 WATER-IN-OIL SUSPOEMULSIONS BAYER IP GMBH (DE) 2017-09-13 EP disclosed
EP-0043349-A1 Synergistic agents and method for the selective control of weeds, particularly in cereals and soybeans CIBA-GEIGY AG (CH) 1982-01-06 EP disclosed
EP-0043349-A1 Synergistic agents and method for the selective control of weeds, particularly in cereals and soybeans CIBA-GEIGY AG (CH) 1982-01-06 EP disclosed