Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.80 |
| ▸ | POLB | P06746 | 1/20 | 0.80 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 4/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1105809 | 0.99 | KDM4E (0.77) | KDM4EPOLBRECQLHTTMAPT | |
| Iodide SCHEMBL2057098 | 0.97 | KDM4E (0.75) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL15419914 | 0.97 | KDM4E (0.79) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL16663887 | 0.93 | KDM4E (0.81) | KDM4EPOLBRECQLHTTMAPT | |
| Bromide SCHEMBL8512189 | 0.89 | KDM4E (1.00) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL8022993 | 0.87 | KDM4E (0.97) | KDM4EPOLBRECQLHTTMAPT | |
| Iodide SCHEMBL29210094 | 0.86 | KDM4E (0.94) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL13686278 | 0.85 | KDM4E (0.62) | KDM4EPOLBRECQLBCHEACHE | |
| Bromide SCHEMBL3916333 | 0.84 | KDM4E (0.56) | KDM4EPOLBRECQLHTTMAPT | |
| SCHEMBL13645489 | 0.84 | KDM4E (0.64) | KDM4EPOLBRECQLHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260053393-A1 | NEAR-IR GLUCOSE SENSORS | PROFUSA INC (US) | 2026-02-26 | — | — | US | disclosed |
| US-20250230174-A1 | NEAR-IR GLUCOSE SENSORS | PROFUSA, INC. (US) | 2025-07-17 | — | — | US | disclosed |
| US-12285250-B2 | Near-IR glucose sensors | PROFUSA, INC (US) | 2025-04-29 | — | — | US | disclosed |
| EP-3813667-A1 | NEAR-IR GLUCOSE SENSORS | Profusa, Inc. (US) | 2021-05-05 | — | — | EP | disclosed |
| US-20210101915-A1 | NEAR-IR GLUCOSE SENSORS | PROFUSA, INC. (US) | 2021-04-08 | — | — | US | disclosed |
| CN-112601491-A | Near-infrared glucose sensor | 普罗菲尤萨股份有限公司 | 2021-04-02 | — | — | CN | disclosed |
| US-10717751-B2 | Near-IR glucose sensors | PROFUSA, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| EP-3562952-A1 | NEAR-IR GLUCOSE SENSORS | Profusa, Inc. (US) | 2019-11-06 | — | — | EP | disclosed |
| US-20190010170-A1 | NEAR-IR GLUCOSE SENSORS | PROFUSA, INC. (US) | 2019-01-10 | — | — | US | disclosed |
| WO-2018125913-A1 | NEAR-IR GLUCOSE SENSORS | PROFUSA, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
| US-20030207305-A1 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | APPLERA CORPORATION (US) | 2003-11-06 | — | — | US | disclosed |
| US-20030165942-A1 | Compound, especially marker-dye, on the basis of polymethines | DYOMICS GMBH (DE) | 2003-09-04 | — | — | US | disclosed |
| EP-1325084-A2 | PYRIDINE DYES AND QUINOLINE DYES USED AS MARKERS FOR BIOMOLECULES, POLYMERS, MEDICAMENTS, AND PARTICLES | Wolfbeis, Otto Samuel (DE) | 2003-07-09 | — | — | EP | disclosed |
| US-6541618-B1 | Detecting hybrids | APPLERA CORPORATION | 2003-04-01 | — | — | US | disclosed |
| US-6348596-B1 | NUCLEIC ACID HYBRIDIZATION ASSAYS; DNA SEQUENCE DETERMINATION | PE CORPORATION (NY) | 2002-02-19 | — | — | US | disclosed |
| EP-1049744-B1 | ASYMMETRIC CYANINE DYE QUENCHERS | PE CORP NY (US) | 2002-01-23 | — | — | EP | disclosed |
| EP-1049744-A1 | ASYMMETRIC CYANINE DYE QUENCHERS | PE Corporation (NY) (US) | 2000-11-08 | — | — | EP | disclosed |
| US-6080868-A | AS A QUENCHER IN A REPORTER-QUENCHER ENERGY-TRANSFER DYE PAIR FOR NUCLEIC ACID HYBRIDIZATION ASSAYS | THE PERKIN-ELMER CORPORATION (US) | 2000-06-27 | — | — | US | disclosed |
| WO-2000034394-A2 | PYRIDINE DYES AND QUINOLINE DYES USED AS MARKERS FOR BIOMOLECULES, POLYMERS, MEDICAMENTS, AND PARTICLES | WOLFBEIS OTTO SAMUEL (DE) | 2000-06-15 | — | — | WO | disclosed |
| WO-1999037717-A1 | ASYMMETRIC CYANINE DYE QUENCHERS | THE PERKIN-ELMER CORPORATION (US) | 1999-07-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250230174-A1 | NEAR-IR GLUCOSE SENSORS | IRS1, INSR, SLC2A4 | ACHE 2477/4885KDM4E 3160/4885POLB 4452/4885 |
| US-20210101915-A1 | NEAR-IR GLUCOSE SENSORS | IRS1, INSR, SLC2A4 | ACHE 2477/4885KDM4E 3160/4885POLB 4452/4885 |
| US-20260053393-A1 | NEAR-IR GLUCOSE SENSORS | INSR, IRS1, SLC2A4 | ACHE 3703/4885KDM4E 3774/4885POLB 4196/4885 |
| US-20190010170-A1 | NEAR-IR GLUCOSE SENSORS | IRS1, INSR, SLC2A4 | ACHE 2477/4885KDM4E 3160/4885POLB 4452/4885 |
| US-20030165942-A1 | Compound, especially marker-dye, on the basis of polymethines | MKI67, CYBA, IK | ACHE 1739/4885KDM4E 2432/4885POLB 1040/4885 |
| US-20030207305-A1 | Nitro-substituted non-fluorescent asymmetric cyanine dye compounds | NSUN3, NSUN2, NCL | ACHE 2619/4885KDM4E 3334/4885POLB 475/4885 |
| US-12285250-B2 | Near-IR glucose sensors | IRS1, SLC2A4, GPR119 | ACHE 2266/4885KDM4E 1818/4885POLB 4049/4885 |
| US-10717751-B2 | Near-IR glucose sensors | IRS1, G6PD, SLC2A8 | ACHE 203/4885KDM4E 1515/4885POLB 3166/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.