Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | STK17B | O94768 | 1/20 | 0.35 |
| ▸ | CYP19A1 | P11511 | 6/20 | 0.34 |
| ▸ | MAOB | P27338 | 2/20 | 0.34 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.34 |
| ▸ | AR | P10275 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | STAT1 | P42224 | 1/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.32 |
| ▸ | RELA | Q04206 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30891245 | 0.77 | RET (0.40) | RETKDRMEN1POLBKMT2A | |
| SCHEMBL11380880 | 0.77 | RET (0.40) | RETKDRMEN1POLBKMT2A | |
| SCHEMBL22146506 | 0.68 | MAOB (0.38) | RETKDRMEN1POLBKMT2A | |
| SCHEMBL5548145 | 0.64 | RET (0.46) | RETKDRMEN1POLBKMT2A | |
| SCHEMBL11741033 | 0.64 | S100A4 (0.56) | RETKDRMEN1POLBKMT2A | |
| SCHEMBL69430 | 0.63 | PARP1 (0.48) | RETKDRMEN1POLBKMT2A | |
| SCHEMBL69727 | 0.63 | RET (0.53) | RETKDRMEN1POLBKMT2A | |
| SCHEMBL4775874 | 0.63 | RET (0.45) | RETKDRMEN1POLBKMT2A | |
| SCHEMBL1429502 | 0.63 | STK17B (0.46) | RETKDRMEN1POLBKMT2A | |
| SCHEMBL29441433 | 0.61 | MEN1 (0.52) | RETKDRMEN1POLBKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012071458-A1 | HETEROCYCLIC INHIBITORS OF BETA - SECRETASE FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES | ARRAY BIOPHARMA INC. (US) | 2012-05-31 | — | — | WO | disclosed |