Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 9/20 | 0.43 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | GBA1 | P04062 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.40 |
| ▸ | SKP1 | P63208 | 1/20 | 0.40 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CCNC | P24863 | 1/20 | 0.40 |
| ▸ | CDK8 | P49336 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8515292 | 0.82 | MAPT (0.46) | GPR119KITGBA1CKS1BSKP1 | |
| SCHEMBL2014551 | 0.80 | AKT1 (0.46) | GPR119SMARCA2SMARCA4PBRM1KIT | |
| SCHEMBL2015241 | 0.80 | CKS1B (0.49) | GPR119GBA1CKS1BSKP1SKP2 | |
| SCHEMBL2014735 | 0.80 | WNT3A (0.46) | GPR119CKS1BSKP1SKP2PDK2 | |
| SCHEMBL12632947 | 0.79 | RARG (0.48) | GPR119SMARCA2SMARCA4PBRM1PDK2 | |
| SCHEMBL2015814 | 0.78 | ACHE (0.52) | GPR119CKS1BSKP1SKP2MAPT | |
| SCHEMBL2015195 | 0.78 | CKS1B (0.46) | GPR119CKS1BSKP1SKP2RET | |
| Trifluoroacetic Acid SCHEMBL8511757 | 0.78 | RARB (0.40) | — | |
| SCHEMBL12937830 | 0.78 | GPR119 (0.43) | GPR119KITCKS1BSKP1SKP2 | |
| SCHEMBL2017261 | 0.78 | GPR119 (0.49) | GPR119CKS1BSKP1SKP2PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |