Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CKS1B | P61024 | 2/20 | 0.45 |
| ▸ | SKP1 | P63208 | 2/20 | 0.45 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.45 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.43 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.43 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SQOR | Q9Y6N5 | 1/20 | 0.41 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | DTYMK | P23919 | 1/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2014735 | 0.82 | WNT3A (0.46) | CKS1BSKP1SKP2GPR119ACHE | |
| SCHEMBL9961630 | 0.81 | CKS1B (0.65) | AKT1POLBCKS1BSKP1SKP2 | |
| SCHEMBL2015814 | 0.80 | ACHE (0.52) | CKS1BSKP1SKP2GPR119ACHE | |
| SCHEMBL8514101 | 0.80 | GPR119 (0.43) | CKS1BSKP1SKP2SMARCA2SMARCA4 | |
| SCHEMBL3637662 | 0.80 | GRIA1 (0.55) | AKT1POLBCKS1BSKP1SKP2 | |
| SCHEMBL2017261 | 0.80 | GPR119 (0.49) | CKS1BSKP1SKP2GPR119PDK2 | |
| SCHEMBL2015195 | 0.80 | CKS1B (0.46) | CKS1BSKP1SKP2GPR119ACHE | |
| SCHEMBL8515152 | 0.79 | GPR119 (0.48) | CKS1BSKP1SKP2GPR119KIT | |
| SCHEMBL2015994 | 0.79 | RARA (0.50) | CKS1BSKP1SKP2SMARCA2SMARCA4 | |
| SCHEMBL12632947 | 0.79 | RARG (0.48) | SMARCA2SMARCA4PBRM1GPR119PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2513057-A1 | SPHINGOSINE KINASE INHIBITORS | Merck Patent GmbH (DE) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011072791-A1 | SPHINGOSINE KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2011-06-23 | — | — | WO | disclosed |