Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.38 |
| ▸ | DAO | P14920 | 1/20 | 0.38 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.37 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.37 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.37 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2830618 | 0.82 | MEN1 (0.51) | MEN1KMT2ALMNAKDM4EPDE4D | |
| Hydrochloric Acid SCHEMBL1375056 | 0.80 | MEN1 (0.50) | MEN1KMT2ALMNAKDM4EPDE4D | |
| SCHEMBL14556062 | 0.76 | KDM4E (0.40) | MEN1KMT2ALMNAGABRR1KDM4E | |
| SCHEMBL4362757 | 0.72 | MEN1 (0.39) | MEN1KMT2ALMNAGABRR1KDM4E | |
| SCHEMBL8515102 | 0.72 | RAB9A (0.49) | LMNAKDM4EMAPTGAAALDH1A1 | |
| SCHEMBL14487981 | 0.69 | GABRR1 (0.48) | MEN1KMT2ALMNAGABRR1KDM4E | |
| SCHEMBL8801602 | 0.68 | CYP1A2 (0.40) | MEN1KMT2ALMNAGABRR1KDM4E | |
| SCHEMBL4350884 | 0.68 | LMNA (0.39) | MEN1KMT2ALMNAGABRR1KDM4E | |
| SCHEMBL4362752 | 0.67 | MEN1 (0.38) | MEN1KMT2ALMNAGABRR1KDM4E | |
| SCHEMBL31358629 | 0.67 | HCAR2 (0.40) | MEN1KMT2ALMNAKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069175-A1 | NEW PYRAZOLE DERIVATIVES HAVING CRTH2 ANTAGONISTIC BEHAVIOUR | ALMIRALL, S.A. (ES) | 2012-05-31 | — | — | WO | disclosed |
| EP-2457900-A1 | New pyrazole derivatives having CRTh2 antagonistic behaviour | Almirall, S.A. (ES) | 2012-05-30 | — | — | EP | disclosed |