Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALPL | P05186 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 5/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | S100A9 | P06702 | 1/20 | 0.33 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.33 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL28094438 | 0.98 | ALPL (0.45) | ALPLKMT2AMEN1PLAUGAA | |
| SCHEMBL789628 | 0.82 | ALPL (0.47) | ALPLKMT2AMEN1PLAUGAA | |
| SCHEMBL925314 | 0.81 | ALPL (0.46) | ALPLKMT2AMEN1GAANPC1 | |
| SCHEMBL15524943 | 0.81 | ALPL (0.46) | ALPLKMT2AMEN1PLAUGAA | |
| SCHEMBL20680406 | 0.80 | LMNA (0.39) | KMT2AMEN1PLAUALDH1A1S100A9 | |
| Hydrochloric Acid SCHEMBL28833376 | 0.78 | LMNA (0.38) | KMT2AMEN1PLAUALDH1A1S100A9 | |
| SCHEMBL30989718 | 0.78 | ALPL (0.44) | ALPLKMT2AMEN1NPC1POLB | |
| SCHEMBL25886719 | 0.78 | ALPL (0.44) | ALPLKMT2AMEN1NPC1POLB | |
| SCHEMBL27675010 | 0.77 | ALDH1A1 (0.37) | KMT2APOLBALDH1A1MAPTNPSR1 | |
| SCHEMBL28936653 | 0.77 | NPC1 (0.42) | KMT2AMEN1GAANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2643317-A1 | BENZOXAZEPINES AS INHIBITORS OF P13K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | Exelixis, Inc. (US) | 2013-10-02 | — | — | EP | disclosed |
| WO-2012071519-A1 | BENZOXAZEPINES AS INHIBITORS OF P13K/MTOR AND METHODS OF THEIR USE AND MANUFACTURE | EXELIXIS, INC. (US) | 2012-05-31 | — | — | WO | disclosed |