Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DKK1 | O94907 | 3/20 | 0.52 |
| ▸ | RBP4 | P02753 | 6/20 | 0.39 |
| ▸ | KMO | O15229 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.36 |
| ▸ | TTR | P02766 | 3/20 | 0.36 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8511678 | 0.94 | DKK1 (0.58) | DKK1RBP4KMOROCK2ROCK1 | |
| SCHEMBL8514887 | 0.93 | DKK1 (0.45) | DKK1KMOAAK1 | |
| SCHEMBL8515838 | 0.88 | DKK1 (0.49) | DKK1KMOROCK2 | |
| Ammonia Solution, Strong SCHEMBL8587136 | 0.86 | DYRK1A (0.43) | DKK1RBP4KMO | |
| SCHEMBL8512439 | 0.86 | DKK1 (0.56) | DKK1KMOROCK2 | |
| Hydrochloric Acid SCHEMBL8513412 | 0.85 | DKK1 (0.55) | DKK1KMOROCK2 | |
| SCHEMBL8510671 | 0.85 | DKK1 (0.44) | DKK1KMO | |
| SCHEMBL8514134 | 0.82 | DKK1 (0.42) | DKK1KMO | |
| SCHEMBL8510840 | 0.81 | KMO (0.43) | DKK1KMO | |
| SCHEMBL8510734 | 0.81 | ZAP70 (0.41) | DKK1KMOROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |
| WO-2012069852-A1 | PHARMACEUTICAL COMPOUNDS AS INHIBITORS OF SPHINGOSINE KINASE | ALMAC DISCOVERY LIMITED (GB) | 2012-05-31 | — | — | WO | disclosed |