SCHEMBL8516070

SCHEMBL8516070

CC(C)N(CCOc1ccc2nc(Cc3ccc(F)cc3)sc2c1)C(C)C

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 1/20 0.47
MAPT P10636 2/20 0.46
HTT P42858 1/20 0.46
TDP1 Q9NUW8 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
ADORA2A P29274 1/20 0.45
ADORA1 P30542 1/20 0.45
LMNA P02545 1/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
KMT2A Q03164 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP2D6 P10635 1/20 0.43
APP P05067 1/20 0.42
CACNA1B Q00975 3/20 0.40
HDAC6 Q9UBN7 1/20 0.40
ACHE P22303 2/20 0.39
CA1 P00915 1/20 0.37
CA2 P00918 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8358462 0.89 ACHE (0.48) LTA4HMAPTHTTLMNAKMT2A
SCHEMBL8357917 0.88 HTT (0.48) LTA4HMAPTHTTTDP1L3MBTL1
SCHEMBL8359973 0.86 LMNA (0.60) LTA4HMAPTHTTTDP1L3MBTL1
SCHEMBL8357758 0.83 MAPT (0.44) LTA4HMAPTHTTTDP1L3MBTL1
SCHEMBL8357941 0.82 MAPT (0.48) MAPTHTTTDP1L3MBTL1LMNA
SCHEMBL8361601 0.82 MAPT (0.65) MAPTHTTTDP1L3MBTL1LMNA
SCHEMBL8552900 0.82 LMNA (0.53) LTA4HMAPTHTTTDP1L3MBTL1
SCHEMBL8355856 0.79 APP (0.65) MAPTHTTTDP1L3MBTL1NPC1
SCHEMBL8361528 0.77 NPC1 (0.51) LTA4HMAPTHTTTDP1L3MBTL1
SCHEMBL8552785 0.77 LMNA (0.49) MAPTHTTTDP1L3MBTL1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5919807-A ANTICHOLESTEROL AGENTS DR. KARL THOMAE GMBH (DE) 1999-07-06 US disclosed
EP-0824529-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM Dr. Karl Thomae GmbH (DE) 1998-02-25 EP disclosed
WO-1996035681-A1 BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM DR. KARL THOMAE GMBH (DE) 1996-11-14 WO disclosed