Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.52 |
| ▸ | HTT | P42858 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | LSS | P48449 | 2/20 | 0.42 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | APP | P05067 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8359973 | 0.93 | LMNA (0.60) | LMNACYP1A2CYP2D6HTTMAPT | |
| SCHEMBL8361490 | 0.90 | LMNA (0.53) | LMNACYP1A2CYP2D6HTTMAPT | |
| SCHEMBL8551252 | 0.90 | LMNA (0.50) | LMNACYP1A2CYP2D6HTTMAPT | |
| SCHEMBL8357758 | 0.88 | MAPT (0.44) | LMNACYP1A2CYP2D6HTTMAPT | |
| SCHEMBL8552785 | 0.86 | LMNA (0.49) | LMNACYP1A2CYP2D6HTTMAPT | |
| SCHEMBL8361945 | 0.85 | LMNA (0.51) | LMNACYP1A2CYP2D6HTTLSS | |
| SCHEMBL8357917 | 0.84 | HTT (0.48) | LMNACYP1A2CYP2D6HTTMAPT | |
| SCHEMBL8551381 | 0.83 | CACNA1B (0.45) | LMNACYP1A2CYP2D6MAPTCACNA1B | |
| SCHEMBL8356218 | 0.83 | LMNA (0.60) | LMNACYP1A2CYP2D6HTTLTA4H | |
| SCHEMBL8357933 | 0.82 | HTT (0.56) | LMNACYP1A2CYP2D6HTTLSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824529-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035681-A1 | BENZOTHIAZOLES AND BENZOXAZOLES, AS WELL AS DRUGS CONTAINING THEM, THEIR USE AND METHODS OF PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-11-14 | — | — | WO | disclosed |