Trifluoroacetic Acid

Trifluoroacetic Acid

SCHEMBL8516225

CCN(CC)C(=O)Cn1cc(-c2nc3ccc(C(=O)OC)cc3n(CC3CCCNC3)c2=O)c2ccccc21.O=C(O)C(F)(F)F

nearest known ligand 0.39

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Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 1/20 0.39
ACP1 P24666 3/20 0.38
GHSR Q92847 1/20 0.38
CFTR P13569 2/20 0.37
ALDH1A1 P00352 1/20 0.37
LMNA P02545 1/20 0.37
HTT P42858 1/20 0.37
HIF1A Q16665 1/20 0.37
NPSR1 Q6W5P4 1/20 0.37
ACSS2 Q9NR19 1/20 0.37
CCNT1 O60563 1/20 0.36
CDK7 P50613 1/20 0.36
CDK9 P50750 1/20 0.36
CCNH P51946 1/20 0.36
MNAT1 P51948 1/20 0.36
MEN1 O00255 1/20 0.36
KMT2A Q03164 1/20 0.36
PTGER4 P35408 1/20 0.35
PADI4 Q9UM07 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Trifluoroacetic Acid SCHEMBL8368507 0.92 BRD4 (0.43) BRD4ACP1GHSRCFTRACSS2
Trifluoroacetic Acid SCHEMBL8517318 0.90 BRD4 (0.46) BRD4ACP1GHSRALDH1A1LMNA
Trifluoroacetic Acid SCHEMBL8365272 0.88 BRD4 (0.40) BRD4ACP1GHSRALDH1A1LMNA
Trifluoroacetic Acid SCHEMBL8516379 0.87 ALDH1A1 (0.42) BRD4ACP1GHSRCFTRALDH1A1
Trifluoroacetic Acid SCHEMBL8516454 0.85 CNR2 (0.41) BRD4ACP1GHSRCFTRACSS2
Trifluoroacetic Acid SCHEMBL8516675 0.85 KMT2A (0.38) CFTRALDH1A1LMNAHIF1AACSS2
Trifluoroacetic Acid SCHEMBL8362794 0.84 CFTR (0.42) CFTRLMNAACSS2MEN1KMT2A
Trifluoroacetic Acid SCHEMBL8368543 0.83 CFTR (0.42) CFTRALDH1A1ACSS2MEN1KMT2A
Trifluoroacetic Acid SCHEMBL4687029 0.82 BRD4 (0.51) BRD4GHSRCCNT1CDK7CDK9
Trifluoroacetic Acid SCHEMBL8516818 0.82 CFTR (0.42) CFTRALDH1A1NPSR1ACSS2MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1999046260-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO claimed
WO-1999046260-A1 NEW COMPOUNDS ASTRAZENECA AB (SE) 1999-09-16 WO disclosed