Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | MGLL | Q99685 | 2/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8516519 | 0.71 | TLR8 (0.50) | TLR8SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL13975421 | 0.70 | TLR8 (0.49) | TLR8SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL11116166 | 0.69 | KMT2A (0.41) | TLR8SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL1224966 | 0.69 | TLR8 (0.41) | TLR8SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL8591844 | 0.68 | QPCT (0.43) | TLR8ALDH1A1KMT2APOLBCYP2D6 | |
| SCHEMBL3691691 | 0.68 | FDPS (0.48) | TLR8SMN1; SMN2NPC1RAB9AL3MBTL1 | |
| SCHEMBL8830778 | 0.68 | LTA4H (0.47) | TLR8ALDH1A1KMT2APOLBCYP1A2 | |
| SCHEMBL8649807 | 0.67 | FDPS (0.47) | TLR8ALDH1A1KMT2ACYP1A2ADORA2A | |
| SCHEMBL9822957 | 0.67 | TBXAS1 (0.43) | TLR8ALDH1A1KMT2APOLBCYP2D6 | |
| SCHEMBL1011992 | 0.67 | TBXAS1 (0.43) | TLR8ALDH1A1KMT2APOLBCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE33125-E | HYPOTENSIVE AGENTS | RORER PHARMACEUTICAL CORPORATION (US) | 1989-12-05 | — | — | US | disclosed |
| US-4460585-A | HYPOTENSIVE AGENTS | WILLIAM H. RORER, INC. (US) | 1984-07-17 | — | — | US | disclosed |
| US-4452980-A | DIARRHEA | WILLIAM H. RORER, INC. (US) | 1984-06-05 | — | — | US | disclosed |
| US-4406897-A | 6-Aryl-4-hydrazinyl-s-triazin-2-ones | WILLIAM H. RORER, INC. (US) | 1983-09-27 | — | — | US | disclosed |
| US-4338441-A | CYCLIZATION OF AMIDINOUREA OR AMIDINOTHIOUREA WITH ACTIVE METHYLIDENE COMPOUND | WILLIAM H. RORER, INC. (US) | 1982-07-06 | — | — | US | disclosed |
| US-4246409-A | ANTIDIARRHEAL AGENTS | WILLIAM H. RORER, INC. (US) | 1981-01-20 | — | — | US | disclosed |
| US-4225315-A | Triazinones from amidinoureas | WILLIAM H. RORER, INC. (US) | 1980-09-30 | — | — | US | disclosed |