Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.57 |
| ▸ | ST14 | Q9Y5Y6 | 7/20 | 0.56 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.56 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.56 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.56 |
| ▸ | PLG | P00747 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.47 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 6/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL851208 | 0.91 | GPR119 (0.53) | GPR119ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL851653 | 0.87 | ST14 (0.74) | ST14PRSS1PRSS2PRSS3PLG | |
| SCHEMBL851530 | 0.85 | ST14 (0.52) | ST14PRSS1PRSS2PRSS3PLG | |
| SCHEMBL850947 | 0.83 | ST14 (0.55) | ST14PRSS1PRSS2PRSS3PLG | |
| SCHEMBL851603 | 0.82 | PTPN2 (0.58) | GPR119ST14PRSS1PRSS2PRSS3 | |
| SCHEMBL851458 | 0.82 | GPR119 (0.55) | GPR119ALDH1A1S1PR2 | |
| SCHEMBL851830 | 0.82 | ST14 (0.54) | ST14PRSS1PRSS2PRSS3PLG | |
| SCHEMBL851366 | 0.81 | ST14 (0.50) | ST14PRSS1PRSS2PRSS3PLG | |
| SCHEMBL851954 | 0.81 | ST14 (0.48) | ST14PRSS1PRSS2PRSS3PLG | |
| SCHEMBL851641 | 0.81 | ST14 (0.47) | ST14PRSS1PRSS2PRSS3PLG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2014-07-17 | — | — | US | disclosed |
| US-8722930-B2 | Protease inhibitors | ORION CORPORATION (FI) | 2014-05-13 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133748-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | GPR119 3130/4885ST14 216/4885PRSS1 3/4885 |
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | GPR119 3130/4885ST14 216/4885PRSS1 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.