Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN2 | P17706 | 1/20 | 0.58 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.58 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.58 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.52 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.51 |
| ▸ | F2 | P00734 | 4/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 4/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 4/20 | 0.48 |
| ▸ | ST14 | Q9Y5Y6 | 4/20 | 0.48 |
| ▸ | PLG | P00747 | 3/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | STS | P08842 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509553 | 0.86 | F2 (0.52) | PTPN2PTPN1PTPN6GPR119NPC1 | |
| SCHEMBL852205 | 0.84 | F2 (0.51) | PTPN2PTPN1PTPN6GPR119S1PR2 | |
| SCHEMBL8509771 | 0.83 | DRD2 (0.47) | GPR119RAB9AS1PR2F2PRSS1 | |
| SCHEMBL8509807 | 0.83 | DRD2 (0.47) | GPR119RAB9AS1PR2F2PRSS1 | |
| SCHEMBL851416 | 0.83 | DRD2 (0.47) | GPR119RAB9AS1PR2F2PRSS1 | |
| SCHEMBL851673 | 0.82 | GPR119 (0.57) | GPR119NPC1RAB9AS1PR2F2 | |
| SCHEMBL852001 | 0.82 | F2 (0.60) | RAB9AS1PR2F2PRSS1PRSS2 | |
| SCHEMBL8509703 | 0.81 | F2 (0.67) | NPC1RAB9AS1PR2F2PRSS1 | |
| SCHEMBL851809 | 0.81 | F2 (0.67) | NPC1RAB9AS1PR2F2PRSS1 | |
| SCHEMBL851253 | 0.81 | F2 (0.52) | RAB9AS1PR2F2PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2014-07-17 | — | — | US | disclosed |
| US-8722930-B2 | Protease inhibitors | ORION CORPORATION (FI) | 2014-05-13 | — | — | US | disclosed |
| US-20120136002-A1 | PROTEASE INHIBITORS | AURIGENE DISCOVERY TECHNOLOGIES LIMITED (IN) | 2012-05-31 | — | — | US | disclosed |
| EP-2432556-A1 | PROTEASE INHIBITORS | Orion Corporation (FI) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010133748-A1 | PROTEASE INHIBITORS | ORION CORPORATION (FI) | 2010-11-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140200225-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | PTPN2 3273/4885PTPN1 2266/4885PTPN6 2767/4885 |
| US-20120136002-A1 | PROTEASE INHIBITORS | SERPINB1, TMPRSS15, PRSS1 | PTPN2 3273/4885PTPN1 2266/4885PTPN6 2767/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.