Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FNTA | P49354 | 13/20 | 0.66 |
| ▸ | FNTB | P49356 | 13/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.62 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.60 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8517000 | 1.00 | FNTA (0.66) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8369449 | 0.88 | FNTA (0.68) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8369448 | 0.88 | FNTA (0.68) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL24105605 | 0.85 | TAS1R3 (0.49) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL8896137 | 0.83 | TAS1R3 (0.63) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL7232898 | 0.83 | TAS1R3 (0.63) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL2323686 | 0.82 | L3MBTL1 (0.74) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL18095164 | 0.82 | L3MBTL1 (0.74) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 | |
| SCHEMBL7403502 | 0.82 | ALDH1A1 (0.65) | — | |
| Trifluoroacetic Acid SCHEMBL8364428 | 0.81 | FNTA (0.62) | FNTAFNTBL3MBTL1TAS1R3TAS1R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0817630-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-01-27 | — | — | EP | disclosed |
| EP-0817630-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | Merck & Co., Inc. (US) | 1998-01-14 | — | — | EP | disclosed |
| US-5578629-A | ANTICARCINOGENIC AGENTS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| WO-1996030015-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-10-03 | — | — | WO | disclosed |
| US-5534537-A | Prodrugs of inhibitors of farnesyl-protein transferase | MERCK & CO., INC. (US) | 1996-07-09 | — | — | US | disclosed |