Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.37 |
| ▸ | PLA2G7 | Q13093 | 2/20 | 0.35 |
| ▸ | CCR2 | P41597 | 4/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 4/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR1A | P08908 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR7 | P34969 | 1/20 | 0.33 |
| ▸ | HRH1 | P35367 | 1/20 | 0.33 |
| ▸ | DRD3 | P35462 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8378215 | 0.94 | CXCR3 (0.35) | MCHR1PLA2G7CCR2DRD2 | |
| SCHEMBL8591797 | 0.92 | DRD2 (0.38) | DRD2L3MBTL1HTR1AHTR2AHTR2C | |
| SCHEMBL8374698 | 0.90 | ALDH1A1 (0.36) | BCHEMAPTGPBAR1 | |
| SCHEMBL8375951 | 0.87 | BCHE (0.30) | BCHE | |
| SCHEMBL8517857 | 0.86 | HTR1A (0.35) | DRD2HTR1AHTR2AHTR2CHTR7 | |
| SCHEMBL8377618 | 0.84 | S1PR5 (0.35) | MCHR1PLA2G7CCR2DRD2HRH1 | |
| SCHEMBL8518068 | 0.82 | HDAC3 (0.39) | MCHR1CCR2DRD2 | |
| SCHEMBL8517128 | 0.81 | MAPT (0.37) | MAPTL3MBTL1HTR1AHTR7DRD3 | |
| SCHEMBL8518266 | 0.81 | DRD2 (0.41) | DRD2L3MBTL1HTR1AHTR2AHTR2C | |
| SCHEMBL8377485 | 0.79 | ALDH1A1 (0.36) | MCHR1BCHEMAPTHRH1GPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900199-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | claimed |
| WO-1997041099-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | claimed |
| EP-0900199-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997041099-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1997-11-06 | — | — | WO | disclosed |