SCHEMBL8517324

SCHEMBL8517324

Nc1ccc(Cc2cccc(C(=O)O)c2N)cc1C(=O)O

nearest known ligand 0.68

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.68
CASP6 P55212 2/20 0.68
CDC25B P30305 1/20 0.68
RCE1 Q9Y256 1/20 0.68
TSHR P16473 2/20 0.46
KDM4E B2RXH2 3/20 0.46
KMT2A Q03164 2/20 0.46
GFER P55789 1/20 0.46
RXFP1 Q9HBX9 1/20 0.46
MAPT P10636 2/20 0.45
GAA P10253 1/20 0.45
HPGD P15428 1/20 0.45
ALOX15 P16050 1/20 0.45
HSD17B10 Q99714 1/20 0.45
MCL1 Q07820 2/20 0.45
MEN1 O00255 1/20 0.45
USP2 O75604 1/20 0.45
POLB P06746 1/20 0.45
THRB P10828 1/20 0.45
PKM P14618 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26567800 0.84 ALDH1A1 (0.72) ALDH1A1CASP6CDC25BRCE1TSHR
SCHEMBL3361331 0.82 TSHR (0.57) ALDH1A1CASP6TSHRALOX15G6PD
SCHEMBL29832194 0.82 ALDH1A1 (1.00) ALDH1A1CASP6CDC25BRCE1TSHR
SCHEMBL4444648 0.82 G6PD (0.59) ALDH1A1CASP6TSHRALOX15G6PD
SCHEMBL107442 0.82 ALDH1A1 (1.00) ALDH1A1CASP6CDC25BRCE1TSHR
SCHEMBL30934865 0.82 G6PD (0.59) ALDH1A1CASP6TSHRALOX15G6PD
SCHEMBL29861837 0.82 ALDH1A1 (1.00) ALDH1A1CASP6CDC25BRCE1TSHR
Ammonia Solution, Strong SCHEMBL8509203 0.80 ALDH1A1 (0.96) ALDH1A1CASP6CDC25BRCE1TSHR
Phosphine SCHEMBL21753935 0.80 ALDH1A1 (0.96) ALDH1A1CASP6CDC25BRCE1TSHR
SCHEMBL7781040 0.80 TSHR (0.51) ALDH1A1CASP6CDC25BRCE1TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-11140031-A None JP disclosed
JP-H11140031-A PRODUCTION OF DIAMINODIPHENYLMETHANEDICAROXYLIC ACID NIPPON MEKTRON LTD 1999-05-25 JP disclosed