Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 9/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 7/20 | 0.62 |
| ▸ | PDE3B | Q13370 | 6/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.62 |
| ▸ | LMNA | P02545 | 3/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.62 |
| ▸ | USP2 | O75604 | 2/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.62 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | TSHR | P16473 | 2/20 | 0.62 |
| ▸ | PDE4A | P27815 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | PDE2A | O00408 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | PDE5A | O76074 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Papaverine SCHEMBL34702 | 0.77 | PDE10A (1.00) | PDE10APDE3APDE3BSMN1; SMN2LMNA | |
| Papaverine SCHEMBL29360983 | 0.77 | PDE10A (1.00) | PDE10APDE3APDE3BSMN1; SMN2LMNA | |
| SCHEMBL2935686 | 0.77 | HPGD (0.41) | SMN1; SMN2LMNAUSP2ALDH1A1RAB9A | |
| Papaverine SCHEMBL9551009 | 0.77 | PDE10A (1.00) | PDE10APDE3APDE3BSMN1; SMN2LMNA | |
| Papaverine SCHEMBL29387160 | 0.77 | PDE10A (1.00) | PDE10APDE3APDE3BSMN1; SMN2LMNA | |
| Papaverine SCHEMBL677440 | 0.76 | PDE10A (0.97) | PDE10APDE3APDE3BSMN1; SMN2LMNA | |
| Papaverine SCHEMBL29356374 | 0.76 | PDE10A (1.00) | PDE10APDE3APDE3BSMN1; SMN2LMNA | |
| Papaverine SCHEMBL29696479 | 0.76 | PDE10A (1.00) | PDE10APDE3APDE3BSMN1; SMN2LMNA | |
| SCHEMBL1445574 | 0.76 | PDE10A (1.00) | PDE10APDE3APDE3BSMN1; SMN2LMNA | |
| Papaverine SCHEMBL8691148 | 0.76 | PDE10A (0.97) | PDE10APDE3APDE3BSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5981521-A | USEFUL FOR TREATING VARIOUS HORMONE DEPENDENT DISEASES, INCLUDING PROSTATE CANCER, ENDOMETRIOSIS, UTERINE FIBROIDS, PRECOCIOUS PUBERTY, BENIGN PROSTATE HYPERTROPY AND IN VITRO FERTILIZATION | ABBOTT LABORATORIES (US) | 1999-11-09 | — | — | US | disclosed |