Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.39 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
| ▸ | F12 | P00748 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | NCF1 | P14598 | 1/20 | 0.38 |
| ▸ | NOS3 | P29474 | 1/20 | 0.38 |
| ▸ | NOS1 | P29475 | 1/20 | 0.38 |
| ▸ | NOS2 | P35228 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8519177 | 0.77 | PDE10A (0.62) | HPGDALDH1A1KDM4ERAB9AACHE | |
| SCHEMBL27373826 | 0.75 | PLAU (0.37) | ALDH1A1RAB9ACYP2A6F12PLAU | |
| SCHEMBL232662 | 0.71 | ACHE (0.49) | RAB9ACYP2A6F12PLAUNCF1 | |
| SCHEMBL29373118 | 0.71 | ACHE (0.49) | RAB9ACYP2A6F12PLAUNCF1 | |
| SCHEMBL7826992 | 0.71 | ACHE (0.39) | ALDH1A1RAB9ACYP2A6F12PLAU | |
| SCHEMBL28444367 | 0.70 | L3MBTL1 (0.45) | ALDH1A1SMN1; SMN2CYP1A2GRM5TDP1 | |
| SCHEMBL30542089 | 0.69 | ACHE (0.48) | RAB9ACYP2A6F12PLAUNCF1 | |
| Bromide SCHEMBL28325156 | 0.69 | ACHE (0.48) | RAB9ACYP2A6F12PLAUNCF1 | |
| SCHEMBL1445724 | 0.69 | ADRA2A (0.53) | ALDH1A1KDM4ERAB9ACYP2A6F12 | |
| Bromide SCHEMBL5146705 | 0.69 | ACHE (0.48) | RAB9ACYP2A6F12PLAUNCF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 52 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100075385-A1 | O-Methyltransferases of Tetrahydrobenzylisoquinoline Alkaloid Biosynthesis in Papaver Somniferum | DONALD DANFORTH PLANT SCIENCE CENTER (US) | 2010-03-25 | — | — | US | claimed |
| US-20090222957-A1 | REGULATORY PROTEIN-REGULATORY REGION ASSOCIATIONS RELATED TO ALKALOID BIOSYNTHESIS | CERES INC. (US) | 2009-09-03 | — | — | US | claimed |
| EP-1866418-A2 | MODULATING PLANT ALKALOIDS | Ceres Inc. (US) | 2007-12-19 | — | — | EP | claimed |
| WO-2007117693-A2 | REGULATORY PROTEIN-REGULATORY REGION ASSOCIATIONS RELATED TO ALKALOID BIOSYNTHESIS | CERES, INC. (US) | 2007-10-18 | — | — | WO | claimed |
| WO-2006091676-A2 | MODULATING PLANT ALKALOIDS | CERES INC. (US) | 2006-08-31 | — | — | WO | claimed |
| WO-2005021763-A2 | O-METHYLTRANSFERASES OF TETRAHYDROBENZYLISOQUINOLINE ALKALOID BIOSYNTHESIS IN PAPAVER SOMNIFERUM | JOHNSON & JOHNSON RESEARCH PTY LTD (AU) | 2005-03-10 | — | — | WO | claimed |
| EP-1512748-A1 | O-methyltransferases of tetrahydrobenzylisoquinoline alkaloid biosynthesis in papaver somniferum | Johnson & Johnson Research Pty Limited (AU) | 2005-03-09 | — | — | EP | claimed |
| WO-2004084801-A2 | TREATMENTS FOR LEISHMANIASIS | SMITHSONIAN TROPICAL RESEARCH INSTITUTE (US) | 2004-10-07 | — | — | WO | claimed |
| CN-107778235-B | New crystal form of tetrahydrobenzyl isoquinoline compound and preparation method and application thereof | 四川科瑞德制药股份有限公司 | 2026-02-27 | — | — | CN | disclosed |
| CN-107778235-B | New crystal form of tetrahydrobenzyl isoquinoline compound and preparation method and application thereof | 四川科瑞德制药股份有限公司 | 2026-02-27 | — | — | CN | disclosed |
| CN-114716375-A | Preparation method of tetrahydrobenzyl isoquinoline compound | 四川科瑞德制药股份有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-114716375-A | Preparation method of tetrahydrobenzyl isoquinoline compound | 四川科瑞德制药股份有限公司 | 2022-07-08 | — | — | CN | disclosed |
| CN-114716375-A | Preparation method of tetrahydrobenzyl isoquinoline compound | 四川科瑞德制药股份有限公司 | 2022-07-08 | — | — | CN | disclosed |
| EP-2230312-A1 | Probe compound for detecting and isolating enzymes and means and methods using the same | Helmholtz-Zentrum für Infektionsforschung GmbH (DE) | 2010-09-22 | — | — | EP | disclosed |
| WO-2003000898-A1 | PLANT GENES INVOLVED IN DEFENSE AGAINST PATHOGENS | SYNGENTA PARTICIPATIONS AG (CH) | 2003-01-03 | — | — | WO | disclosed |
| US-20020142281-A1 | Method for modifying a biosynthetic pathway | MENDEL BIOTECHNOLOGY, INC. | 2002-10-03 | — | — | US | disclosed |
| WO-2002074917-A2 | METHOD FOR MODIFYING A BIOLOGICAL PATHWAY | MENDEL BIOTECHNOLOGY, INC. (US) | 2002-09-26 | — | — | WO | disclosed |
| EP-1173459-A4 | CODEINONE REDUCTASE FROM ALKALOID POPPY | JOHNSON & JOHNSON RES PTY LTD (AU) | 2002-09-11 | — | — | EP | disclosed |
| EP-1173459-A1 | CODEINONE REDUCTASE FROM ALKALOID POPPY | Johnson & Johnson Research Pty Limited (AU) | 2002-01-23 | — | — | EP | disclosed |
| WO-2000058333-A1 | CODEINONE REDUCTASE FROM ALKALOID POPPY | JOHNSON & JOHNSON RESEARCH PTY. LIMITED (AU) | 2000-10-05 | — | — | WO | disclosed |