SCHEMBL8519607

SCHEMBL8519607

CCc1ccc2c(c1)OBO2

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.42
TRPA1 O75762 1/20 0.40
CYP1A2 P05177 1/20 0.39
CYP2A6 P11509 1/20 0.39
MAPK1 P28482 2/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
ALDH1A1 P00352 2/20 0.38
NPC1 O15118 1/20 0.38
LMNA P02545 1/20 0.38
MAPT P10636 1/20 0.38
RAB9A P51151 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38
MEN1 O00255 1/20 0.35
KMT2A Q03164 1/20 0.35
TAAR1 Q96RJ0 2/20 0.34
SLC6A2 P23975 2/20 0.34
SLC6A4 P31645 2/20 0.34
SLC6A3 Q01959 2/20 0.34
TSHR P16473 1/20 0.33
ATM Q13315 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8518550 0.83 CNR1 (0.42) TRPA1ALDH1A1TAAR1SLC6A2SLC6A4
SCHEMBL11576986 0.75
SCHEMBL13071242 0.75 TRPA1 (0.44) PARP1TRPA1CYP1A2CYP2A6MAPK1
SCHEMBL4422164 0.74 CYP3A4 (0.58) PARP1CYP1A2L3MBTL1ALDH1A1NPC1
SCHEMBL9588776 0.72 ALOX15 (0.53) PARP1TRPA1CYP1A2CYP2A6MAPK1
SCHEMBL14615927 0.71 TRPA1 (0.41) PARP1TRPA1CYP1A2CYP2A6MAPK1
SCHEMBL10921758 0.71 PARP1 (0.40) PARP1TRPA1CYP1A2CYP2A6MAPK1
SCHEMBL2663369 0.71 CTNNB1 (0.41) PARP1TRPA1NPC1RAB9ASLC6A4
SCHEMBL2663547 0.71 PARP1 (0.40) PARP1TRPA1CYP1A2CYP2A6MAPK1
SCHEMBL8518629 0.70 CYP1A2 (0.38) TRPA1CYP1A2CYP2A6ALDH1A1LMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0679662-B1 Catalyst component for the polymerization of olefins NIPPON OIL CO LTD (JP) 1999-07-14 EP disclosed
US-5728641-A Catalyst component for the polymerization of olefins NIPPON OIL COMPANY, LIMITED (JP) 1998-03-17 US disclosed
EP-0679662-A1 Catalyst component for the polymerization of olefins NIPPON OIL CO. LTD. (JP) 1995-11-02 EP disclosed