Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | TYR | P14679 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 6/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 6/20 | 0.38 |
| ▸ | RAB9A | P51151 | 4/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | BCHE | P06276 | 5/20 | 0.35 |
| ▸ | ACHE | P22303 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7523329 | 0.83 | NR1H2 (0.42) | TSHRLMNAKIF11NR1H2NR1H3 | |
| SCHEMBL9633698 | 0.80 | NR1H2 (0.46) | TSHRLMNATYRKIF11NR1H2 | |
| Methane SCHEMBL27469130 | 0.79 | NR1H2 (0.45) | TSHRLMNATYRKIF11NR1H2 | |
| SCHEMBL8983871 | 0.75 | LMNA (0.40) | LMNAKDM4EALDH1A1 | |
| SCHEMBL10319202 | 0.75 | TSHR (0.46) | TSHRLMNATYRKIF11NR1H2 | |
| SCHEMBL8755288 | 0.75 | ACHE (0.40) | LMNARAB9APOLBL3MBTL1ACHE | |
| SCHEMBL8382993 | 0.75 | TSHR (0.46) | TSHRLMNATYRKIF11NR1H2 | |
| SCHEMBL12688243 | 0.74 | NR1H2 (0.54) | TSHRLMNATYRKIF11NR1H2 | |
| SCHEMBL17678821 | 0.74 | TSHR (0.50) | TSHRLMNATYRKIF11NR1H2 | |
| SCHEMBL20332823 | 0.74 | TSHR (0.50) | TSHRLMNATYRKIF11NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5962435-A | ANTICHOLESTEROL AGENT | HOECHST MARION ROUSSEL, INC. (US) | 1999-10-05 | — | — | US | disclosed |
| CN-1216921-A | Method for inducing vascular cell adhesion molecule-1 and treating chronic inflammatory diseases using 2, 6-dialkyl-4-silyl-phenols | HOECHST MARION ROUSSEL INC (US) | 1999-05-19 | — | — | CN | disclosed |
| US-5795876-A | ANTIINFLAMMATORY AGENTS | HOECHST MARION ROUSSSEL, INC. (US) | 1998-08-18 | — | — | US | disclosed |
| US-5677291-A | Method of lowering serum cholesterol levels with 2,6-di-alkyl-4-silyl-phenols | HOECHST MARION ROUSSEL, INC. (US) | 1997-10-14 | — | — | US | disclosed |