Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 8/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 8/20 | 0.42 |
| ▸ | KIF11 | P52732 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | ORAI1 | Q96D31 | 1/20 | 0.35 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.35 |
| ▸ | ORAI3 | Q9BRQ5 | 1/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8522012 | 0.83 | TSHR (0.41) | NR1H2NR1H3KIF11LMNAALDH1A1 | |
| SCHEMBL9223317 | 0.82 | NR1H2 (0.53) | NR1H2NR1H3KIF11TAAR1ALDH1A1 | |
| SCHEMBL7524213 | 0.79 | TSHR (0.41) | TAAR1ALDH1A1TSHRIDO1CES2 | |
| SCHEMBL8983879 | 0.78 | PTPN1 (0.42) | NR1H2NR1H3KIF11TAAR1ALDH1A1 | |
| SCHEMBL7523490 | 0.78 | NR1H2 (0.42) | NR1H2NR1H3KIF11TAAR1ALDH1A1 | |
| SCHEMBL9662228 | 0.77 | NR1H2 (0.47) | NR1H2NR1H3KIF11LMNAHTT | |
| SCHEMBL7863483 | 0.77 | ACHE (0.36) | NR1H2NR1H3LMNAHTTTAAR1 | |
| SCHEMBL9563524 | 0.75 | NR1H2 (0.41) | NR1H2NR1H3KIF11LMNAHTT | |
| SCHEMBL8755288 | 0.75 | ACHE (0.40) | LMNAHTTTAAR1ALDH1A1IDO1 | |
| SCHEMBL8983871 | 0.75 | LMNA (0.40) | LMNATAAR1ALDH1A1IDO1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900225-B1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | AVENTIS PHARMA INC (US) | 2002-01-30 | — | — | EP | disclosed |
| EP-0900225-A1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997041129-A1 | ALKYL-4-SILYL-PHENOLS AND ESTERS THEREOF AS ANTIATHEROSCLEROTIC AGENTS | HOECHST MARION ROUSSEL, INC. (US) | 1997-11-06 | — | — | WO | disclosed |
| US-5608095-A | Alkyl-4-silyl-phenols and esters thereof as antiatherosclerotic agents | HOECHST MARION ROUSSEL, INC. (US) | 1997-03-04 | — | — | US | disclosed |