Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 6/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | QPCT | Q16769 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9271416 | 0.85 | QPCT (0.44) | POLBLMNASMN1; SMN2NPC1MEN1 | |
| SCHEMBL8949312 | 0.81 | LMNA (0.48) | POLBLMNASMN1; SMN2NPC1MEN1 | |
| SCHEMBL7879569 | 0.78 | QPCT (0.49) | POLBLMNASMN1; SMN2NPC1MEN1 | |
| SCHEMBL13696720 | 0.78 | CYP11B1 (0.55) | SMN1; SMN2QPCT | |
| SCHEMBL7868665 | 0.78 | SMN1; SMN2 (0.41) | TBXAS1POLBLMNASMN1; SMN2NPC1 | |
| SCHEMBL8949449 | 0.77 | ALDH1A1 (0.56) | POLBLMNASMN1; SMN2NPC1MEN1 | |
| SCHEMBL8445979 | 0.76 | ALDH1A1 (0.64) | TBXAS1POLBSMN1; SMN2NPC1MEN1 | |
| SCHEMBL8444382 | 0.76 | GSK3A (0.48) | POLBLMNASMN1; SMN2NPC1MEN1 | |
| SCHEMBL8949297 | 0.76 | SMN1; SMN2 (0.52) | POLBLMNASMN1; SMN2NPC1MEN1 | |
| Hydrochloric Acid SCHEMBL8949432 | 0.76 | ALDH1A1 (0.55) | POLBLMNASMN1; SMN2NPC1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618907-B1 | 1-(ARYLALKYL-AMINOALKYL)IMIDAZOLE DERIVATIVES, PROCESSES OF PREPARATION AND USE AS THERAPEUTICAL AGENTS | BRITISH TECH GROUP INT (GB) | 1999-04-28 | — | — | EP | disclosed |