Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.61 |
| ▸ | NAALAD2 | Q9Y3Q0 | 1/20 | 0.59 |
| ▸ | MME | P08473 | 8/20 | 0.59 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.56 |
| ▸ | CPA1 | P15085 | 1/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.54 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA2 | P00918 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9068704 | 0.88 | ACE (0.62) | ACENAALAD2MMECPA1ACE2 | |
| SCHEMBL22115354 | 0.87 | ACE (0.47) | ACENAALAD2MME | |
| SCHEMBL4147877 | 0.86 | NAALAD2 (0.61) | ACENAALAD2MMEFOLH1CPA1 | |
| SCHEMBL29726740 | 0.86 | NAALAD2 (0.69) | ACENAALAD2MMEFOLH1CPA1 | |
| SCHEMBL4147882 | 0.86 | NAALAD2 (0.61) | ACENAALAD2MMEFOLH1CPA1 | |
| SCHEMBL11277926 | 0.85 | CA2 (0.55) | ACEMMEFOLH1CA1CA2 | |
| SCHEMBL4582086 | 0.85 | CHRND (0.60) | ACENAALAD2MMEFOLH1CPA1 | |
| SCHEMBL4629789 | 0.85 | NAALAD2 (0.59) | ACENAALAD2MMEFOLH1CA1 | |
| SCHEMBL4582092 | 0.85 | CHRND (0.60) | ACENAALAD2MMEFOLH1CPA1 | |
| SCHEMBL10824355 | 0.85 | NAALAD2 (0.59) | ACENAALAD2MMEFOLH1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900197-A1 | BETA-THIOPROPIONYL-AMINOACID DERIVATIVES AND THEIR USE AS BETA-LACTAMASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1999-03-10 | — | — | EP | claimed |
| WO-1997030027-A1 | BETA-THIOPROPIONYL-AMINOACID DERIVATIVES AND THEIR USE AS BETA-LACTAMASE INHIBITORS | SMITHKLINE BEECHAM PLC (GB) | 1997-08-21 | — | — | WO | claimed |